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转移性结直肠癌患者应用贝伐株单抗联合FOLFIRI化疗方案治疗的临床价值 被引量:3

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摘要 目的:探究转移性结直肠癌患者应用贝伐株单抗联合FOLFIRI化疗方案治疗的临床价值。方法:选取我院2012年1月-2015年6月收治的转移性结直肠癌患者13例作为研究组,采取伐株单抗联合FOLFIRI化疗方案治疗;并选取2010年1月-2011年12月收治的转移性结直肠癌患者13例作为对照组,采取FOLFIRI化疗方案治疗。对比两组治疗效果及安全性。结果:研究组治疗后总有效率高于对照组,差异有统计学意义(P<0.05);两组毒副反应发生率差异无统计学意义(P>0.05)。结论:转移性结直肠癌患者应用贝伐株单抗联合FOLFIRI化疗方案治疗效果良好,患者症状有所改善,药物副反应率较高,但程度较轻,考虑化疗引起,患者治疗过程中耐受性较好,可推广应用。
出处 《医学理论与实践》 2017年第11期1620-1622,共3页 The Journal of Medical Theory and Practice
作者简介 本文通讯作者:金建华
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  • 1Price TJ,Peeters M,Kim TW.ASPECCT研究:帕尼单抗的疗效与西妥昔单抗相当[J].中华结直肠疾病电子杂志,2014,3(2):6-6. 被引量:17
  • 2Jemal A, Bray F, Center MM, et al. Global cancer statistics[ J]. CA Cancer J Clin, 2011 ; 61 : 69 -90.
  • 3Chibaudel B, Bonnetain F, Tournigand C, et al. Simplified prognos- tic model in patients with oxaliplatin - based oririnotecan - based first -line chemotherapy for metastatic colorectal cancer: aGERCOR study[J]. Oncologist, 2011 ;16:1228 - 1238.
  • 4Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors[ J]. JNCI, 2000; 92: 205-216.
  • 5Giessen C, yon WLF, Hinke A, et al. A randomized, phase III trial of capecitabine plus bevacizumab (Cape - Bey ) versus capecitabine plus irinotecan plus bevacizumab (CAPIRI - Bey) in first- line treatment of metastatic colorectal cancer: the AIO KRK0110 trial/ML22011 trial[J]. BMC Cancer, 2011;11: 367.
  • 6Souglakos J, Ziras N, Kakolyris S, et al. Randomised phase - II trial of CAPIRI (capecitabine, irinotecan) plus bevacizumab vs FOLFIRI (folinic acid, 5 -fluorouracil, irinotecan ) plus bevacizumab as first - line treatment of patients with unresectable/metastatic colorec- tal cancer (mCRC) [ J ]. Br J Cancer, 2012 ; 106 : 453 - 459.
  • 7Sugihara K,Uetake H. Therapeutic strategies for hepatic metastasisof colorectal cancer : overview [ J ]. J Hepatobiliary Pancreat Sci,2012,19:523 —527.
  • 8Caceres M,Pascual M,Alonso S, et al. Treatment of colorectalcancer with unresectable metastasis with chemotherapy without prima-ry tumor resection : analysis of tumor - related complications[ J]. CirEsp’ 2014,92;30-37.
  • 9Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to e-valuate the response to treatment in solid tumors. European Organiza-tion for Research and Treatment of Cancer, National Cancer Instituteof the United States,National Cancer Institute of Canada. [ J ]. JNatl Cancer Inst, 2000,92:205 -216.
  • 10Jemal A, Bray F, Center MM, et al. Global cancer statistics[ J]. CA Cancer J Clin , 2011,61:69 -90.

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