摘要
目的探讨参附注射液联合化疗治疗急性白血病的临床疗效。方法 94例急性白血病患者被纳入研究并随机分为两组,对照组47例给予单纯化疗治疗,观察组47例加用参附注射液,对比临床疗效。结果观察组治疗有效率高于对照组(P<0.05)。两组治疗后CD4^+、CD4^+/CD8^+均较治疗前明显增加(P<0.05),且组间差异有统计学意义(P<0.05)。两组治疗后CD8+无明显变化(P>0.05),且组间差异无统计学意义(P>0.05)。两组治疗后IL-6、TNF-α均较治疗前明显降低(P<0.05),且组间差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论参附注射液联合化疗治疗急性白血病能提高治疗效果,增强细胞免疫功能,降低炎症因子水平和化疗相关不良反应。
Objective To investigate the clinical effect of Shenfu injection combined with chemotherapy in the treatment of acute leukemia. Methods 94 patients with acute leukemia were included in the study and were randomly divided into two groups. The control group （47 cases） was received chemotherapy alone. The observation group （47 cases） was treated with Shenfu injection. The clinical efficacy was compared. Results The effective rate of the treatment group was significantly higher than which of the control group （P〈0.05）. The CD4^＋, CD4^＋/CD8^＋levels of two groups were significantly higher than pre-treatment （P〈0.05） and it had significantly difference between the two groups （P〈0.05）. There was no significant change in CD8 after treatment in the two groups （P〉0.05）, and there was no significant difference between the two groups （P〉0.05）. IL-6 and TNF-α were significantly lower than pre-treatment （P〈0,05） and it had significant difference between two groups （P〈0.05）. The incidence of adverse reactions in the observation group was significantly lower than the control group （P〈0.05）. Conclusion Shenfu injection combined with chemotherapy in th treatment of acute leukemia can improve the therapeutic effect, enhance the immune function, reduce the level of inflammatory factors and chemotherapy-related adverse reactions.
作者
王秀明
WANG Xiuming(Department of Hematology, Jimo People＇s Hospital, Jimo Shandong 266200, Chin)
出处
《中国继续医学教育》
2017年第9期216-218,共3页
China Continuing Medical Education
关键词
急性白血病
参附注射液
细胞免疫功能
炎症因子
acute leukemia
Shenfu injection
cellular immune /＇unction
inflammatory factors
