摘要
目的研究生长分化因子-15(GDF-15)、心肌梗死标志物[肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)以及肌红蛋白(Mb)]的表达水平。方法临床纳入125例阿克苏地区第一人民医院2014年4月—2015年4月期间收治的急性心肌梗死患者,所有患者按心电图情况分为ST段抬高型心肌梗死(STEMI,n=64)以及非ST段抬高型心肌梗死(NSTEMI,n=61)。同期选取60例阿克苏地区第一人民医院体检中心非心肌梗死志愿者作为对照组。观察三组患者GDF-15、CK-MB、cTnI以及Mb表达水平以及其之间的关系。结果三组患者GDF-15、CK-MB、cTnI以及Mb水平均有差异,P<0.05;STEMI组上述指标水平均明显高于NSTEMI组,NSTEMI组上述指标水平均明显高于对照组,P<0.05。GDF-15与CK-MB、cTnI以及Mb均呈正相关,P<0.05。两组患者GDF-15阳性检出率最高,明显高于其他指标阳性检测率。GDF-15变化检出时间均明显低于其他指标,P<0.05。结论心肌梗死患者心肌梗死标志物表达水平显著升高,且STEMI患者更高。GDF-15水平虽然也有所升高,但不能作为检测急性心肌梗死的重要性指标,与其他指标联合检测可有一定意义和作用。
Objective To study the expression level of growth differentiation factor 15 （GDF-15）,myocardial infarction markers [ereatine kinase isoenzyme （CK-MB）, troponin I （cTnI） and myoglobin （MB）]. Methods 125 eases of patients with acute myocardial infarction admitted to our hospital from April 2014 to April 2015 were clinically included, all patients were divided into ST segment elevation myocardial infarction group （STEMI, n=64） and non-ST segment elevation myocardial infarction group （NSTEMI, n=61 ） by electrocardiogram （ECG）. 60 non myocardial infarction volunteers in physical examination center of our hospital were selected as the control group. The levels of GDF-15, CK-MB, cTnI and Mb were observed and the relationship among patients in three groups were studied. Results The level of GDF-15, CK-MB, cTnI and Mb in three- groups was different, P 〈 0.05; The level of the above indicators in STEMI group were significantly higher than those in NSTEMI group, the level of the above indicators in NSTEMI group were remarkably higher than those in control group, P 〈 0.05. The GDF-15 and CK-MB, cTnI and Mb were all positively correlated, P 〈 0.05. Conclusion The expression level of myocardial infarction markers in patients with myocardial infarction increased significantly, and the STEMI patients were higher. Although the level of GDF-15 also increased, it could not be used as an important indicator for the detection of acute myocardial infarction, it can have certain significance after it is assessed combined with other indicators.
出处
《新疆医学》
2017年第3期264-266,281,共4页
Xinjiang Medical Journal
作者简介
卢志怡，女，主治医师，研究方向：心血管疾病。
