摘要
目的:研究子痫前期患者血清中sEng、ADMA含量与胎盘缺氧损伤、细胞凋亡的相关性。方法:选择2014年5月~2016年3月期间在我院确诊为子痫前期的56例患者作为PE组,同期分娩的健康产妇作为对照组,采集血清并测定sEng、ADMA含量,采集胎盘组织并测定氧化应激指标、细胞凋亡分子的含量。结果:PE组患者血清中sEng、ADMA的含量均显著高于对照组;PE组胎盘组织中SOD、GSH-Px、CAT、SVCT1、SVCT2、Survivin、XIAP的含量均显著低于对照组,Beclin1含量、LC3-II/LC-I比值均显著高于对照组;PE组sEng、ADMA高含量组患者胎盘中Beclin1的含量以及LC3-II/LC-I的比值均显著高于sEng、ADMA低含量组,SOD、GSH-Px、CAT、SVCT1、SVCT2、Survivin、XIAP的含量均显著低于sEng、ADMA低含量组。结论:子痫前期患者血清中sEng、ADMA含量显著升高且与胎盘缺氧损伤、细胞凋亡程度密切相关。
Objective：To study the correlation of serum sEng and ADMA levels with placental hypoxia injury and cell apoptosis in patients with preeclampsia.Methods：A total of 56 patients diagnosed with preeclampsia in our hospital between May 2014 and March 2016 were selected as PE group,healthy subjects giving birth during the same period were selected as control group,serum was collected to determine sEng and ADMA levels,and the placenta tissue was collected to determine the levels of oxidative stress indexes and cell apoptosis molecules.Results：Serum sEng and ADMA levels of PE group were significantly higher than those of control group;SOD,GSH-Px,CAT,SVCT1,SVCT2,Survivin and XIAP levels in placenta tissue of PE group were significantly lower than those of control group while Beclin1 and LC3-Ⅱ/LC-Ⅰratio were significantly higher than those of control group;Beclin1and LC3-Ⅱ/LC-Ⅰratio in placenta of patients with high sEng and ADMA levels within PE group were significantly higher than those of patients with low sEng and ADMA levels while SOD,GSH-Px,CAT,SVCT1,SVCT2,Survivin and XIAP levels were significantly lower than those of patients with low sEng and ADMA levels.Conclusions：Serum sEng and ADMA levels in patients with preeclampsia increase significantly and are closely related to the placental hypoxia injury and cell apoptosis.
出处
《海南医学院学报》
CAS
2017年第5期627-630,共4页
Journal of Hainan Medical University
基金
深圳市科技计划项目(JCYJ20160426094126651)~~
作者简介
向兰花（1982-），女，江西人，主治医师，本科，联系电话：13510745157，电子信箱：uirpxxlhtin@163．com。
