摘要
目的观察尼可地尔治疗射血分数正常的心力衰竭的临床疗效。方法对信阳市中心医院心血管内科收治的因高血压引起的射血分数正常的心力衰竭患者共100例随机进行分组,分为观察组和对照组,各50例。对照组给予常规治疗,观察组在常规治疗基础上加用口服尼可地尔治疗。比较两组患者临床治疗效果、治疗前后超声心电图参数:室间隔厚度(IVST)、左室后壁厚度(LVPWT)、二尖瓣舒张早期流速峰值(E)、二尖瓣舒张晚期流速峰值(A)、二尖瓣环舒张早期流速峰值(e)、E/A、E/e、及6min步行试验距离(6MWY)、N末端脑钠肽前体(NT-proBNP)。结果两组患者治疗结果显示,观察组的总有效率为96.0%显著高于对照组84.0%(P<0.05),治疗后患者的E,e、E/A及6MWY均升高,IVST,LVPWT,A,E/e,NT-proBNP均降低,差异均具有统计学意义(P<0.05)。并且观察组的参数升高及降低幅度均明显高于对照组。结论在常规治疗的基础上加用口服尼可地尔治疗射血分数正常的心力衰竭,能有效改善患者临床症状及舒张功能指标,提高患者心脏舒张功能。
Objective To observe the clinical efficacy of nicorandil in the treatment of heart failure with normal ejection fraction. Methods Totally 100 cases of heart failure patients with normal ejection fraction induced by hypertension were randomly divided into observation group and control group, 50 cases each. The control group was treated with routine therapy, and the observation group was treated with oral nicorandil on the basis of conventional therapy. The interven- tricular septum thickness （IVST） ,left ventricular posterior wall thickness （ LVPWT）, peak early diastolic velocity （ E）, peak velocity of mitral valve diastolic （A） ,Peak early diastolic velocity of mitral valve ring（e） ,E / A, E / e, 6 - min walk test distance （6MWY） and N -terminal pro- brain natriuretic peptide （NT- proBNP） were measured before and after the treatment. Results The total effective rate of the observation group was 96. 0% , which was significantly higher than that of the control group （84. 0% , P 〈 0. 05）. After treatment, E, e, E / A and 6MWY were increased, and IVST, LVPWT, A, E / e and NT - proBNP were all decreased （all P 〈 0. 05）. And the parameters of the observation group were significantly higher and lower than the control group. Conclusion On the basis of conventional treatment with oral administration of nicorandil treatment of ejection fraction of normal heart failure, can effectively improve the pa- tient＇ s clinical symptoms and diastolic function indicators, improve heart diastolic function in patients.
出处
《医药论坛杂志》
2017年第2期66-68,71,共4页
Journal of Medical Forum
关键词
心力衰竭
尼可地尔
射血分数
Heart failure
Nieorandil
Ejection fi＇action
