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早期手术治疗对动脉瘤性蛛网膜下腔出血患者血清炎性细胞因子水平及神经功能的影响 被引量:4

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摘要 目的探讨早期手术治疗对动脉瘤性蛛网膜下腔出血患者血清炎性细胞因子水平及神经功能的影响。方法选取安阳市第二人民医院收治的74例动脉瘤性蛛网膜下腔出血患者,依据不同手术时机分为对照组(发病后<3d)与研究组(发病后>3d)各37例。2组均实施动脉瘤颈夹闭手术治疗。术后随访3个月,统计2组预后情况,并对比2组发病后3d、5d、10d血清炎性细胞因子[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)及白介素-1β(IL-1β)]、神经功能评分(NIHSS)及手术前后生活质量评分。结果 2组发病后3d血清炎性细胞因子水平及NIHSS评分差异均无统计学意义(P>0.05);与对照组相比,研究组发病后5d、10d血清炎性细胞因子TNF-α、IL-6、IL-1β水平及NIHSS评分均较低,差异有统计学意义(P<0.05);2组恢复良好率相比,研究组(35.14%)远高于对照组(13.51%),差异有统计学意义(P<0.05);2组中残、重残、植物生存及病死发生率比较,差异均无统计学意义(P>0.05);术前2组生活质量评分差异均无统计学意义(P>0.05);与对照组比较,研究组术后3个月生活质量评分较高,差异具有统计学意义(P<0.05)。结论对动脉瘤性蛛网膜下腔出血患者予以早期手术治疗,可显著降低患者血清炎性细胞因子水平、恢复神经功能,有效提高生活质量,改善预后。
作者 危保松
出处 《中国实用神经疾病杂志》 2017年第8期70-72,共3页 Chinese Journal of Practical Nervous Diseases
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