摘要
紫苏叶为我国传统清热解毒中药,具有解表散寒、宣肺化痰、行气和胃之功效,临床广泛应用于炎症性疾病的治疗。为明确紫苏叶药理活性的物质基础及其抗炎活性机制,本文依据近年来紫苏叶提取物及主要化学成分药理活性的相关文献,对紫苏叶中挥发油类、黄酮和花色苷类、酚酸类、苷类、三萜类和甾体等主要化学成分、紫苏叶提取物的抗炎活性及其调控固有免疫细胞活性和功能、调节辅助性T细胞平衡等主要作用机制进行了综述,旨在为研发以紫苏叶为原料的抗炎新药提供参考。
Folium Perillae（FP） is a traditional Chinese materia medica, which has been used for treating inflammatory diseases. In order to clarify the material basis of FP′s pharmacological activity and anti-inflammatory mechanism, we presented a review about some of the primary chemical components in FP, such as volatile oils, flavonoids, anthocyanins, phenolic acids, glycosides, triterpenes and steroids,and about the anti-inflammatory activity of FP extract and its major mechanism, such as regulating the viability and function of innate immune cells, controlling the balance of helper T cells, based on related research in recent years. This study aims to provide reference for further research and development of new drugs based on FP.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2017年第3期279-286,共8页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金(81473398)
中国医学科学院医学与健康创新工程-重大协同创新项目(2016-I2M-2-006)~~
关键词
紫苏叶
化学成分
炎症
Folium Perillae
chemical constituents
inflammation
作者简介
杨慧，女，硕士研究生，主要从事抗炎免疫药理学研究，Tel：（010）63165192，E-mail：yanghui@imm．ac．cn
通讯作者：林明宝，E-mail：mingbaolin@imm．cams．cn，Tel（010）63165192；
通讯作者：侯琦，E-mail：houq@imm．ac．cn，Tel（010）63165191
