摘要
目的探讨多西他赛联合顺铂或替吉奥治疗局部晚期胃癌疗效及对血清肿瘤及转移侵袭相关指标的影响。方法以2013年2月至2015年10月我院收治的90例局部晚期胃癌患者为研究对象,随机数字表法均分研究组及对照组各45例,对照组实施多西他赛联合顺铂治疗,研究组实施多西他赛联合替吉奥治疗,观察治疗前后2组血清肿瘤及转移侵袭相关指标[神经元特异性烯醇化酶(NSE)、癌胚抗原125(CA125)、重组人S100钙结合蛋白A4(S100A4)、腺苷酸活化蛋白激酶5(ARK5)、乙酰肝素酶-1(HPA-1)]、近期疗效、生活质量[肿瘤患者卡氏功能评分(Karnofaky)]及毒副反应。结果治疗前2组NSE、CA125、S100A4、HPA-1、ARK5、Karnofaky评分相较差异无统计学意义(P>0.05);治疗后2组NSE、CA125、S100A4、HPA-1、ARK5较治疗前明显降低,Karnofaky评分明显升高,且治疗后研究组的改善幅度明显大于对照组,差异有统计学意义(P<0.05);研究组近期总有效率89%较对照组明显高,药物毒副反应总发生率51%明显低,差异有统计学意义(P<0.05)。结论多西他赛联合替吉奥治疗局部晚期胃癌时,显著降低血清肿瘤及转移侵袭相关指标表达,提高近期疗效及预后生活质量,减少毒副反应,较其联合顺铂更具优势。
Objective To explore the effects of docetaxel combined with cisplatin or S-1 in the treatment of locally advanced gastric cancer and the effect on related serum indexes of tumor and metastases invasion. Methods From February 2013 to October 2015, 90 cases with locally advanced gastric cancer in our hospital were enrolled in the study. By the random number table method, they were divided into the study group and the control group, 45 cases in each group. The control group was treated with docetaxel combined with cisplatin while the study group was treated with docetaxel combined with S-1. The related serum indexes of tumor and metastases invasion [neuron specific enolase （NSE）, carcinoembryonic antigen 125 （CA125）, recombinant humanS100 calcium binding protein A4 （S100A4）, adenosine monophosphate activated protein kinase 5 （ARK5）, heparanase-1 （HPA- 1）7, short-term curative effect, quality of life FKarnofsy score of tumor patients （Karnofaky）] and adverse reactions were observed before and after treatment. Results Before treatment, there were no significant differences in NSE, CA125, S100A4, HPA-1, ARK5 and Karnofaky scores between the two groups （P〉0.05）. After treatment, NSE, CA125, S100A4, HPA-1 and ARK5 decreased significantly while Karnofaky scores increased significantly, and the decrease and increase in the study group were more significant than those in the control group （P 〈0.05）. The short-term total effective rate of the study group was significantly higher than that of the control group, and the total incidence of adverse drug reactions was significantly lower （P〈0.05）. Conclusion Docetaxel combined with S-1 in the treatment of locally advanced gastric cancer can significantly reduce the expression of related serum indexes of tumor and metastasis invasion, improve the curative effect, the prognosis and the quality of life, and reduce the adverse reactions.
作者
张杭
蔡慧
李勃
马立业
Zhang Hang Cai Hui Li Bo Ma Liye(Department of General Surgery, Changhai Hospital of the Second Military Medical University, Shanghai 200433, Chin)
出处
《山西医药杂志》
CAS
2017年第5期507-510,共4页
Shanxi Medical Journal
关键词
胃肿瘤
晚期
顺铂
多西他赛
替吉奥
Stomach neoplasms, advanced
Cisplatin
Docetaxel
S-1
作者简介
通信作者：马立业，Email：2939981186@qq．com
