摘要
目的观察潜艇艇员执行任务前后皮肤屏障功能指标变化,评价潜艇封闭作业环境对人体皮肤屏障功能的影响。方法在潜艇某部执行任务前,单纯随机抽样选取青年男性艇员30例为研究对象,分别在潜航任务前(T_0)、>2个月任务结束后48 h(T_1)两个时间点对受试者前额、手背、腹部3个部位进行无创检测并进行比较。检测指标包括角质层含水量(stratum corneum hydration,SCH)、黑素指数(melanin index,MI)、红斑指数(erythema index,EI)及经皮肤水分丢失(transepidermal water loss,TEWL)等。结果 T_1与T_0相比,受试者前额及手背MI、EI显著降低,腹部MI、EI无明显变化;前额、手背、腹部SCH、TEWL值无明显变化;但T_1时间点受试者前额、手背、腹部皮肤经胶带黏膜后TEWL上升幅度均高于T_0(P<0.05);且3 h后TEWL恢复比例降低。结论潜艇封闭环境长期(>2个月)作业后,人体角质层完整性、皮肤屏障修复功能和色素屏障将受到影响,但SCH和TEWL未见明显差异。
Objective To investigate the effects of closed working environment in submarine on human skin barrier function.Methods Thirty cases of young men were simply randomly selected.Indicators of skin barrier functions including stratum corneum hydration（SCH）, melanin index（MI）, erythema index（EI） and transepidermal water loss（TEWL） were noninvasively detected and compared on three sites of skin（forehead, back of hand, and abdomen） of every subject at two different time point of before（T0） and 48 hours after（T1） submarine commission respectively.Results MI and EI of the subjects＇ forehead and back at T1 decreased significantly compared with those at T0.There was no significant change in MI and EI of abdominal skin.SCH and TEWL of all three sites of skins varied little between T0 and T1 after tape strips.TEWL increased significantly on skins of forehead, back of hand, and abdomen at T1 comparing with those at T0（P〈0.05）, and the recovery rate decreased（P〈0.05）.Conclusion A long term（2 months） work in a closed environment as submarine will impair human stratum corneum integrity and pigment barrier, but impact little on SCH and TEWL as observed.
出处
《解放军医学院学报》
CAS
2017年第2期147-150,共4页
Academic Journal of Chinese PLA Medical School
基金
中华医学会-薇姿研究项目(V2014100606)
作者简介
门月华，女，博士，主治医师。研究方向：皮肤屏障与皮肤外科。Email：menyuehua@126．com
通信作者：李健，男，博士，主治医师。Email：doctor-lijian@qq．com
