摘要
目的探讨心肌酶学快速床旁检测（POCT）项目筛选对心肌梗死（AMI）的早期诊断价值。方法选取2014年1月至2016年1月在郑州市第三人民医院确诊的AMI患者80例作为AMI组，以同期80例健康体检者作为健康对照组。检测两组血清心肌肌钙蛋白I（cTnI）、肌酸激酶同工酶（CK—MB）、肌红蛋白（MYO），比较两组3项指标单用及联合应用的区别；采用受试者工作特征曲线，评价3项指标单用及联用对诊断AMI的价值。结果cTnI诊断AMI的敏感度高于MYO和CK—MB（85％比80％、75％）；诊断AMI的特异度，3项指标则无显著差异（分别为85．5％、85．0％、83．8％）；3项联合检测的敏感度和特异度最高，分别为95％和92．5％，明显高于3项单独检测。结论cTnI、MYO、CK—MB3项联合检测在诊断早期AMI的敏感度特异度最高，可作为早期AMI的POCT方法。
Objective To investigate the value of rapid bedside detection of myocardial enzymes （POCT） in the early diagnosis of myocardial infarction （AMI）. Methods 80 patients with myocardial infarction （AMI group） 80 cases of healthy people （normal control group） admitted to the Third People＇s Hospital of Zhengzhou City from January 2014 to January 2016 were enrolled, the serum cardiac troponin I （eTnI）, creatine kinase （CK）, creatine kinase-myocardial isoenzyme （CK-MB）, myoglobin （MYO） were detected in two groups the differences between single and combined application of three indicators were compared. Receiver operating characteristic curve （ROC） was used to evaluate the value of three indicators in the diagnosis of AMI by single and combined application. Results The sensitivity of eTnI was higher than that of MYO and CK-MB （85% vs. 80%, 75%）. The specificity of three indicators was no significant difference （85.5%, 85%, 83.8%, respectively）. The sensitivity and specificity of three indicators combined application were the highest （95% and 92.5%, respectively） , significantly higher than that of single detection in the diagnosis of AMI . Conclusion The sensitivity and specificity of cTnI, CK-MB , MYO combined application were the highest, can be used as an POCT method in the early diagnosis of AMI.
作者
郭瑞静
GUO Rui-jing(Department of Clinical Laboratory, the Third People＇s Hospital of Zhengzhou City, Zhengzhou 450000, Chin)
出处
《实用检验医师杂志》
2016年第4期199-201,共3页
Chinese Journal of Clinical Pathologist
关键词
心肌梗死
急性
肌钙蛋白I
肌红蛋白
肌酸激酶同工酶
Acute myocardial infarction, cardiac troponin I. myoglobin, creatine kinase isoenzyme
作者简介
通讯作者：郭瑞静，Email：986608179@qq．com
