摘要
目的观察齐拉西酮对老年脑器质性精神障碍患者的治疗效果及其对糖脂代谢、瘦素、催乳素的影响。方法选择2014年1月—2015年12月衢州市第三医院老年科老年脑器质性精神障碍患者170例作为研究对象,将其分为观察组(齐拉西酮组)和对照组(奥氮平组),每组85例。测定治疗前后阳性和阴性症状量表评分(positive and negative symptoms scale scores,PANSS)和糖脂代谢指标及瘦素、催乳素水平。结果观察组总有效率和对照组比较差异无统计学意义(P>0.05)。2组患者治疗后PANSS评分均低于治疗前(P<0.05),观察组治疗后PANSS评分低于对照组(P<0.05)。治疗后,对照组体重指数、空腹血糖、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三酯均高于治疗前(P<0.05),观察组体重指数、空腹血糖、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三酯和治疗前比较差异无统计学意义(P>0.05),对照组体重指数、空腹血糖、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三酯均高于观察组(P<0.05)。治疗后,对照组瘦素水平高于治疗前(P<0.05),催乳素水平低于治疗前(P>0.05),观察组和治疗前比较差异无统计学意义(P>0.05),对照组瘦素水平高于观察组(P<0.05),催乳素水平低于观察组(P<0.05)。结论齐拉西酮对老年脑器质性精神障碍患者治疗效果显著,对患者的糖脂代谢、瘦素和催乳素水平无明显影响。
Objective To observe the therapeutic effect of ziprasidone on senile organic mental disorders and its effect on glycolipid metabolism, leptin and prolactin. Methods We selected 170 patients with organic mental disorders as the sub- jects,and divided them into two groups： the observation group （ziprasidone group） and the control group （Olanzapine group） ,with 85 cases in each group. The positive and negative symptoms scale scores （ PANSS）, glycolipid metabolism, leptin and prolactin levels were measured before and after treatment. Results The total effective rate of the observation group and the control group had no statistically significant difference（P 〉 0.05 ）. The PANSS scores after treatment of the two groups were lower than those before treatment（P 〈 0.05）, and the PANSS scores of the observation group were lower than those of the control group after treatment （ P 〈 0.05 ）. After treatment, the body mass index, fasting blood glucose, high density lipoprotein, low density lipoprotein, total cholesterol and triglyceride in the control group were higher than those before treatment （P 〈 0.05 ）. There were no significant differences of body mass index, fasting blood glucose, high density lipoprotein,low density lipoprotein, total cholesterol and triglyceride with those before treatment in the observation group（P 〉 0.05 ）. The body mass index,fasting blood glucose, high density lipoprotein, low density lipoprotein, total cho- lesterol and triglyceride in the control group were higher than those in the observation group （ P 〈 0.05 ）. After treatment, the level of leptin in the control group was higher than that before treatment（P 〈 0.05 ）, the level of prolactin was lower than that before treatment（P 〉0.05 ）. There was no significant difference of leptin and prolactin in observation group be- fore treatment（ P 〉 0.05 ）. The level of leptin in control group was higher than that in observation group（ P 〈 0.05 ）, and the level of prolactin was lower than that in observation group （P 〈 0.05）. Conclusion The effect of ziprasidone on the treatment of organic mental disorders in elderly patients is significant, and there is no significant effect on the glycolipid metabolism,leptin and prolactin
出处
《中华全科医学》
2017年第3期475-478,共4页
Chinese Journal of General Practice
基金
2016年浙江省科技厅公益技术研究社会发展项目(2016C33237)
浙江省衢州市2014年度指导性科技项目(2014144)
关键词
齐拉西酮
老年
精神障碍
瘦素
催乳素
Ziprasidone
Senile
Mental disorders
Leptin
Prolactin
作者简介
通信作者：祝云龙，E-mail：Zuhe9115@163．com
