摘要
目的:观察雷贝拉唑联合盐酸伊托必利治疗老年胃食管反流症的临床疗效。方法:选取132例老年胃食管反流症患者,随机分为两组,实验组(67例)接受口服雷贝拉唑联合盐酸伊托必利治疗;对照组(65例)口服奥美拉唑联合盐酸伊托必利治疗。通过比较两组不适症状消失时间,治疗有效率,以及副作用发生情况比较两组疗效。结果:实验组胸骨后灼热感、胃部反酸、胃部疼痛等症状消失时间分别为(9.65±2.66)d、(11.23±3.48)d、(5.86±1.57)d;对照组上述症状消失时间分别为(15.24±2.43)d、(16.44±3.51)d、(8.32±1.74)d。实验组临床治疗有效率为91.04%,副作用发生率为11.94%;对照组临床治疗有效率为70.77%,副作用发生率为10.78%。与对照组相比,实验组各项症状消失时间明显较短,P<0.05,治疗有效率(91.04%)明显较高,P<0.05;同时两组副作用发生率无显著差异。结论:在老年胃食管反流症的治疗中,雷贝拉唑联合盐酸伊托必利可以显著改善不适症状,提高临床疗效,同时无明显副作用,值得临床推广。
Objective：To observe the clinical effect of Rabeprazole combined with hydrochloride in the treatment of gastroesophageal reflux disease in the elderly.METHODS：One hundred and thirty-two elderly patients with gastroesophageal reflux disease were randomly divided into two groups. The experimental group（n = 67）was treated with Rabeprazole and hydrochloride,while the control group（n =65）was treated with omeprazole and hydrochloride. The author through two groups of patients with symptoms of discomfort disappeared,treatment efficiency,and the occurrence of side effects,compared the efficacy of two methods.Results：The time of disappearance of symptoms such as sternal burning sensation,gastric acid regurgitation and stomach pain in the experimental group were（9.65±2.66）days,（11.23±3.48）days and（5.86±1.57）days respectively. The time of disappearance of the symptoms in the control group was（15.24±2.43）days,（16.44±3.51）days and（8.32±1.74）days,respectively. The effective rate of clinical treatment was 91.04%,the side effect rate was 11.94%. The effective rate of the control group was 70.77% and the side effect rate was 10.78%.Compared with the control group,the symptoms of patients in the experimental group disappeared significantly lower time,P 0.05,the treatment efficiency was significantly higher,P0.05; while the incidence of side effects was no significant difference between the two groups,P0.05.Conclusion：Rabeprazole combined with hydrochloride can significantly improve the symptoms of patients and improve the clinical curative effect in elderly patients with gastroesophageal reflux disease without significant side effects,which is worthy of clinical application.
出处
《北方药学》
2017年第2期9-10,共2页
Journal of North Pharmacy
关键词
雷贝拉唑
盐酸伊托必利
胃食管反流
老年
Rabeprazole
Itopride hydrochloride
Gastroesophageal reflux
Elderly
