摘要
目的:分析2009~2010年上海市精神卫生中心住院的精神疾病患者抗抑郁药的处方情况。方法:采用1日法对2009年12月1日及2010年12月1日本中心所有住院患者抗抑郁药处方情况进行调查。结果:2009年(2 011例)及2010年(1 434例)住院患者精神疾病分布无明显变化,由高到低为精神分裂症、器质性精神障碍和心境障碍;抗抑郁药处方应用频率最多的精神疾病依次为心境障碍、器质性精神障碍、精神分裂症;处方频率最高的抗抑郁药种类依次为选择性5-羟色胺再摄取抑制剂(SSRIs)、其他机制抗抑郁药(文拉法辛、米氮平、曲唑酮)及三环类抗抑郁药;且抗抑郁药的处方剂量与限用日剂量比值均接近1;抗抑郁药处方方式以单一种抗抑郁药最常见;抗抑郁药联合治疗中最常见的其他精神药物依次为抗精神病药、镇静催眠药和心境稳定剂;合并1种药物的处方为多。结论:2009~2010年SSRIs均为临床一线抗抑郁药,新一代其他机制的抗抑郁药处方明显增加;抗抑郁药处方剂量均在合理范围。
Objective： To analyze the prescriptions of antidepressant drugs in psychiatric inpatients of Shanghai Mental Health Center from 2009 to 2010. Method：Use one day time point survey to investigate the antidepressant prescriptions of all hospitalized patients in Shanghai Mental Health Center on each December 1 st in 2009 and 2010. Results：In 2009 （2 011 cases） and 2010 （ 1 434 cases） ,there was no significant change in the distribution of diseases, which were schizophrenia, organic mental disorder and mood disorder from high to low. The psychiatric disorders that the most frequently used antidepressants were mood disorders, organic mental disorders, schizophrenia and other psychiatric disorders. The highest frequency of antidepressant drugs in turn were selective serotonin reuptake inhibitors （SSRIs） and other antidepressant drugs （represented by venlafax- ine, mirtazapine and trazodone） and tricyclic antidepressants. The ratio of the prescribed dose and the defined daily dose was close to 1. Single antidepressant prescription （monotherapy） was the most common form in the prescription of antidepressant. The most common prescription of combination use of antidepressants and psychotropic drugs was antipsychotic drugs, sedatives hypnotics and mood stabilizers, and combination use of antidepressants with one psychotropics was common. Conclusion： From 2009 to 2010, SSRIs is the first line of antidepressants, and the prescription of the newer generation with other mechanisms of antidepressant prescription drugs increased significantly. The prescription dose of antidepressants are in the reasonable range.
出处
《临床精神医学杂志》
2017年第1期12-14,共3页
Journal of Clinical Psychiatry
基金
国家自然科学基金青年科学基金项目(81201056)
国家自然科学基金重大研究计划(91232719)
上海市卫生系统优秀人才培养项目(XYQ2011014)
上海市科委医学引导类项目(中医)(12401906200)
上海市精神疾病临床医学中心(2014)
国家临床重点专科-上海市精神卫生中心(卫生部医政司2011-873)
"十二五"国家科技支撑项目(2012BAI01B04)
关键词
抗抑郁药处方
住院患者
时点调查
antidepressant prescription
inpatients
time point survey
作者简介
通讯作者：陈俊，doctorcj2010@gmail．com；
方贻儒，yirufang@aliyun．com
