摘要
金樱根为三金片的主要成分,但目前对于金樱根的化学成分和药理作用研究甚少。为了阐明金樱根的物质基础和生物活性,该研究采用硅胶、Sephadex LH-20、MCI gel CHP 20P等柱色谱以及HPLC半制备等方法,对金樱根(Rosa laevigata)的化学成分进行研究。结果表明:从中共分离得到9个化合物,经过波谱数据分析结合文献对照分别鉴定为儿茶素(1),表儿茶素(2),rosamultin(3),sericoside(4),2α,3α,19α,23-tetrahydroxy-urs-12-en-28-oic acid-3-O-β-D-glucopyranosyl ester(5),kaji-ichigoside F1(6),β-D-Glucopyranosyl 3β,19α-dihydroxy-2-oxo-urs-12-en-28-oate(7),胡萝卜苷(8),β-谷甾醇(9),其中化合物2、4、5、7为首次从该植物中分离得到。该研究结果为金樱根在功能医药领域的开发利用提供了理论依据。
The roots of Rosa laevigata were the main ingredients of the Sanjin tablet,at present,the studies on the chemical constituents and pharmacological of the R. laevigata were relatively insufficient. In order to elucidate the material basis and the activity of R. laevigata,the constituents of R. laevigata were isolated by silica gel,Sephadex LH-20,MCI gel CHP 20 P column chromatography and semi-preparative HPLC. Their structures were elucidated by anlalyzing their spectral data and comparing with the previously reported literatures. Nine compounds：（ ＋）-catechin（ 1）,（-）-epicatechin（ 2）,rosamultin（ 3）,sericoside（ 4）,2α,3α,19α,23-tetrahydroxy-urs-12-en-28-oic acid-3-O-β-D-glucopyranosyl ester（ 5）,kaji-ichigoside F1（ 6）,β-D-Glucopyranosy 3β,19α-dihydroxy-2-oxo-urs-12-en-28-oate（ 7）,daucosterol（ 8）,β-sitosterol（ 9） were obtained. Compounds（ 2）,（ 4）,（ 5） and（ 7） were reported from the plant for the first time. The results provide scientific information for exploitation and medicine utilization of R. laevigata.
出处
《广西植物》
CAS
CSCD
北大核心
2017年第2期255-259,共5页
Guihaia
基金
广西壮族自治区"八桂学者"专项~~
关键词
金樱根
化学成分
结构鉴定
roots of Rosa laevigata
chemical constituents
structure identification
作者简介
丁阳（1991-）,男,湖北京山人,硕士研究生,研究方向为中药化学,（E-mail）1184907484@qq.com.
通信作者：李典鹏,博士,研究员,主要从事天然产物物质基础、生物活性及开发利用研究,（E-mail）ldp@gxib.cn.
