摘要
目的分析脑卒中后癫痫发作的临床特点,并对其相关因素进行分析。方法对1 008例脑卒中患者进行回顾性研究,并分析可能影响卒中后继发癫痫发作的相关危险因素。结果脑卒中后癫痫发作的发生率约为5.36%,其中早发型癫痫占63.11%,发作类型以单纯部分发作为主,迟发型癫痫占38.89%,发作类型以全身强直-阵挛发作为主,单因素分析结果显示:性别(x^2=4.12,P=0.042)、糖尿病(x^2=4.89,P=0.027)、肺部感染(x^2=8.95,P=0.003)、病灶部位(x^2=45.14,P<0.001)和病灶范围(x^2=23.32,P<0.001)与卒中后癫痫发作有关;多元Logistic分析结果显示:性别(OR=1.946,95%CI:1.039~3.644)、肺部感染(OR=3.618,95%CI:1.536~8.520)、病灶部位(OR=6.435,95%CI:3.353~12.349)和病灶范围(OR=2.513,95%CI:1.374~4.599)等因素可能与卒中后癫痫发作有关(均有P<0.05)。结论男性,肺部有感染,病灶部位在皮质和病灶范围大可能是卒中后癫痫发作的危险因素。
Objective To study the clinical characteristics of post-stroke epilepsy and analyze the related risk fac- tors of epilepsy onset after stroke. Methods A retrospective study was conducted among 1 008 stroke patients in our hos- pital and the related risk factors for epilepsy onset secondary to stroke were analyzed. Results The incidence of epilepsy after stroke was 5.36% , among which 63.11% was early-onset epilepsy, and simple partial seizure was the predominant seizure type. But only 38.89% was late-onset epilepsy and the seizure type was mainly generalized tonic-clonic seizures. Univariate analysis showed that gender （Z2 =4. 12, P = 0. 042）, diabetes （χ 2=4. 89, P = 0. 027）, pulmonary infection （ χ2 = 8.95, P =0. 003 ）, lesion location （ 2 ： 45. 14,P 〈 0. 001 ） and scope of lesions （ χ2 = 23.32, P 〈 0. 001 ） were associated with seizures after stroke; Multivariate Logistic analysis showed that gender （OR = 1.946, 95% CI： 1.039- 3. 644）, pulmonary infection （ OR = 3. 618,95% CI： 1. 536-8. 520）, lesion location （ OR = 6. 435, 95% CI： 3. 353- 12. 349） and scope of lesions （ OR = 2. 513,95% CI： 1. 374-4. 599） were more prone to seizures after stroke （ all P 〈 0. 05 ）. Conciusions Males, pulmonary infection, lesion location in cortex and the bigger scope of lesions may be the risk factors of secondary epilepsy after stroke.
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2017年第2期179-182,共4页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(81271444)
关键词
卒中
癫痫
危险因素
流行病学方法
Stroke
Epilepsy
Risk factors
Epidemiologic methods
作者简介
徐菲（1982-），女，安徽六安人，主治医师，在读硕士研究生。主要研究方向：癫痫。
通讯作者 王玉，E-mail：yw4d@hotmail．com
