摘要
目的探讨尿酸水平在子痫前期中的诊断意义。方法选择2008年1月至2015年8月在湖南省人民医院产科就诊的孕24～28周的孕妇1357例，其中136例发展为子痫前期，1221例为血压正常孕妇。结果（1）子痫前期组孕妇年龄、分娩时孕周、体重指数、收缩压、舒张压、尿蛋白定量、胆固醇、肌酐、尿酸、尿酸增长值均高于血压正常组；高尿酸血症组子痫前期、剖宫产、胎儿生长受限、小于孕龄儿、新生儿窒息的比率明显高于尿酸正常组（P〈0．05）。（2）多因素Logistic回归分析显示收缩压、尿蛋白定量、尿酸水平都是子痫前期的预测指标，其中尿酸水平的预测能力最强。（3）ROC曲线显示，尿酸增长值预测子痫前期的临界值为112μmol／L，其敏感度85．2％；特异度90．1％。结论尿酸水平可以作为监测子痫前期病理生理变化的重要指标，妊娠早期至妊娠中期的尿酸增长值能较精确地预测子痫前期并评估围生儿的结局。
Objective To explore the diagnostic significance of the uric acid in preeclampsia. Methods The samples were chosen between January 2008 and August 2015 in our hospital maternity clinic, at 24 to 28 weeks of gestation, singletons, 1 357 cases of pregnant women, 136 cases for the develop- ment of preeclampsia, and 1 221 cases of normal pregnancy, the clinical data of 1 357 cases were retrospec- tively analyzed. Results （1） The maternal age, birth gestational age, body mass index, systolic blood pres- sure, diastolic blood pressure, urine protein, cholesterol, creatinine, uric acid, and uric acid increased value of the control group of preeclampsia were significantly higher than the normal group （P 〈 0.05 ）. The incidence of preeclampsia, cesarean delivery rate, fetal growth restriction, small gestational age, and new- born asphyxia rate of high uric acid hematic disease group were significantly higher than the normal group （ P 〈 0. 05 ）. （2） Logistic regression analysis showed that systolic blood pressure, urinary protein and uric acid were the predictors, and uric acid was the best predictor. （3） By using receiver operating characteristic （ROC） curve, the growth of uric acid was 112 μmol/L, and the sensitivity was 85.2% , the specificity was 90. 1%. Conclusions Uric acid level can be used as an important indicator to monitor the pathophysiology of preeclampsia, and uric acid value can be accurately predicted.
作者
陈婷
姚穗
Chen Ting Yao Sui(Department of Obstetrics, Hunan Province People＇s Hospital, Changsha 410005, China)
出处
《中国医师杂志》
CAS
2017年第1期75-78,共4页
Journal of Chinese Physician
