摘要
目的探讨腹腔镜下宫颈癌手术患者地佐辛复合右美托咪定术后镇痛的最佳剂量。方法收集2012年1月~2015年3月医院收治的宫颈癌腹腔镜手术患者120例为研究对象,随机分为A、B、C 3组,各40例,3组术后均给予右美托咪定+地佐辛+0.9%氯化钠+托烷司琼进行镇痛,其中右美托咪定A组的剂量为0.5μg/kg,B组为1.0μg/kg,C组为1.5μg/kg,其余药物的剂量相同。观察比较3组术后不同时间的镇静Ransay评分、疼痛VAS评分及不良反应。结果术后4 h、8 h及12 h,B组与C组的VAS评分明显低于A组(P<0.05);术后4 h、8 h,B组与C组的Ransay评分明显高于A组(P<0.05);术后48 h,患者满意度为B组>A组>C组(P<0.05);术后48 h,C组的不良反应发生率明显高于A组与B组(P<0.05)。结论 0.8 mg/kg地佐辛与1.0μg/kg右美托咪定配伍是腹腔镜下宫颈癌手术患者术后镇痛的最佳剂量,其镇痛效果及安全性良好。
Objective To explore the optimal dosage of dezocine combined with dexmedetomidine for the patients after laparoscopic surgery for cervical cancer. Methods Totally 120 patients suffering cervical cancer to receive laparoscopic surgery in our hospital from Jan. 2012 to Mar. 2015 were selected as research subjects and randomly divided into groups A, B, and C（n = 40,respectively）. After the surgery, the patients in the three groups were administered with dexmedetomidine ＋ dezocine ＋ 0.9% sodium chloride ＋ tropisetron for analgesia, among which the dose of dexmedetomidine is 0.5 μg/kg for group A, 1.0 μg/kg for group B, and1.5 μg/kg for group C, and the other doses are the same in the three groups. The Ransay sedation scores, VAS pain scores and adverse reactions in the three groups at different time were observed compared. Results At 4 h, 8 h and 12 h after the surgery, the VAS scores in groups B and C were significantly lower than those in group A（P〈0.05）; 4 h and 8 h after the surgery, the Ransay scores in groups B and C were significantly higher than those in group A（P〈0.05）; 48 h after the surgery, the satisfaction of patients in group B was significantly higher than that in groups A and C, and that in group A was significantly higher than that in group C（P〈0.05）; 48 h after the surgery, the adverse reaction in group C was significantly higher than that in groups A and B（P〈0.05）.Conclusion Dezocine of 0.8 mg/kg combined with dexmedetomidine of 1.0 μg/kg is the optimal dose for postoperative analgesia of patients with cervical cancer, and both analgesic effects and safety are very good.
出处
《西南国防医药》
CAS
2017年第1期49-51,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
宫颈癌
腹腔镜
地佐辛
右美托咪定
剂量
cervical cancer
laparoscopy
dezocine
dexmedetomidine
dose
