摘要
①目的观察2型糖尿病骨量正常和骨质疏松患者血清胰岛素样生长因子-1(insulin-like growth factor,IGF-1)水平的变化,探讨IGF-1与骨密度的相关性。②方法选取2016年3~8月于我院内分泌科住院的2型糖尿病患者87例。根据骨密度分为观察组和对照组,比较两组间血钙、血磷、碱性磷酸酶、IGF-1、糖化血红蛋白、尿酸、肌酐、甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白、空腹血糖及餐后2h血糖、空腹及餐后2h胰岛素、空腹及餐后2hC肽、性别、年龄、身高、体质量、身体质量指数(BMI)、糖尿病病程、有无高血压的差异。③结果对照组年龄、体质量、BMI、血钙、IGF-1明显高于观察组;观察组内女性、高血压者所占比例高于对照组。④结论 2型糖尿病合并骨质疏松患者血清IGF-1水平降低,年龄、BMI、IGF-1是2型糖尿病患者骨质疏松的危险因素。
Objective To observe and explore the correlationship between bone mineral density and insulin-like growth factor - 1 in type 2 diabetic patients.Methods To selected 87 patients with type 2 diabetes in our hospital from March 2016 to August 2016. Based on bone mineral density was divided into observation group and control group, and compared the differences among blood calcium and blood phosphorus, alkaline phosphatase, IGF-1, glycosylated hemoglobin, uric acid, creatinine, tri- glyceride, total cholesterol, high-density lipoprotein cholesterol,low density lipoprotein cholesterol, fasting blood glucose and postprandial blood glucose, fasting and postprandial 2h insulin, fasting and postprandial 2h C-peptide, gender, age, height, weight, BMI, diabetes duration, the presence of hyper- tension in the two groups.Results Age,weight,BMI,blood calcium and IGF-1 in control group were obviously higher than the observation group; Osteoporosis women, the number of hypertension in ob- servation group was higher than control group.Conclusion The serum IGF-1 level in patients with type 2 diabetes with osteoporosis decrease,age,BMI,IGF-1 are risk factors for type 2 diabetes melli- tus patients with osteoporosis.
作者
魏雨田
吴乃君
金秀平
徐莹
崔士芳
WEI Yutian WU Naijun JIN Xiuping et al(North China University of Science and Technology Affiliated to Hospital, Tangshan 063000, Chin)
出处
《华北理工大学学报（医学版）》
2017年第1期19-22,共4页
Journal of North China University of Science and Technology：Health Sciences Edition
作者简介
魏雨田（1991-），女，硕士研究生。研究方向：内分泌与代谢病性疾病。
