摘要
目的探讨血清降钙素原(PCT)水平对脓毒性休克患儿预后的预测价值。方法选取西安市某医院2014年1月-2015年6月ICU病房收治的68例脓毒性休克患儿为研究对象,于入院后第1,3,6天检测血清PCT水平,同时记录患儿危重病例评分(PCIS)。根据患儿入院后第28天的生存情况将入选患儿分为存活组(30例)和死亡组(38例),比较2组患儿的PCT水平和PCIS评分,并对二者进行相关性分析。结果存活组患儿血清PCT水平随时间的推移呈下降趋势,死亡组患儿血清PCT水平随时间的推移呈上升趋势。存活组患儿第1,3,6天测得的血清PCT水平低于死亡组,差异具有统计学意义(P<0.01)。存活组患儿PCIS评分随时间的推移呈上升趋势,死亡组患儿PCIS评分随时间的推移则呈下降趋势;存活组患儿第1,3,6天PCIS评分高于死亡组,差异有统计学意义(P<0.01);患儿血清PCT水平与PCIS评分呈负相关。结论监测脓毒性休克患儿血清PCT水平的变化可以有效预测患儿的预后。
Objective To investigate the predictive value of serum procalcitonin（PCT）level for the prognosis of children with septic shock.Methods We included a total of 68 children diagnosed with septic shock who were admitted to ICU from January 2014 to June 2015.On Day 1,Day 3and Day 6after admission,the serum PCT level was determined and the pediatric critical illness score（PCIS）was recorded.Based on their survival status on Day 28,these children were divided into the survival group（n=30）and the death group（n=38）.The PCT level and the PCIS score were compared between the two groups,and correlation analysis was also performed.Results In the survival group,the serum PCT level tended to decrease with time;whereas in the death group,the PCT level increased with time.On Day 1,Day 3and Day 6,the serum PCT level was significantly lower in the survival group than that in the death group（P〈0.01）.With time,the PCIS score tended to increase in the survival group but decrease in the death group.On Day 1,Day 3and Day 6,the PCIS score was significantly higher in the survival group than that in the death group（P〈0.01）.The serum PCT level was negatively correlated with the PCIS score.Conclusion For pediatric patients with septic shock,monitoring the changes in the serum PCT level may effectively predict their prognosis.
出处
《保健医学研究与实践》
2016年第6期34-36,39,共4页
Health Medicine Research and Practice
关键词
降钙素原
患儿
脓毒性休克
Procalcitonin
Pediatric patients
Septic shock
作者简介
陈镜（1985-），男，本科，主治医师，E-mail：253119991@qq．com。
通讯作者：高路，E-mail：jzgaolu123@163．com。
