摘要
目的了解2011-2015年陕西省男男性行为者(men who have sex with men,MSM)哨点艾滋病病毒(Human Immunodeficiency Virus,HIV)新发感染状况,探讨其相关影响因素。方法将2011-2015年MSM哨点监测4 609例样本纳入研究,对HIV抗体确证阳性样本使用BED捕获酶联免疫法(BED HIV capture enzyme immunoassay,BED-CEIA,简称BED)进行新发感染检测,估算该人群新发感染率;汇总哨点监测资料,根据新发感染检测结果,采用个体匹配的1∶4病例对照研究及条件logistic回归,分析新发感染影响因素。结果陕西省2011-2015年MSM哨点HIV新发感染率分别为5.00%、6.50%、4.52%、5.78%和4.49%,共发现228例感染者,其中新发感染的比例为47.4%(108/228)。经单因素和多因素条件logistic回归分析,知识知晓(OR=6.993,95%CI:1.961~24.508)和梅毒感染(OR=3.528,95%CI:1.605~7.753)是新发感染的促进因素,最近6个月肛交性行为坚持使用安全套(OR=0.500,95%CI:0.302~0.827)是新发感染的保护因素。结论陕西省MSM哨点HIV新发感染率和新发感染比例较高,应改进该人群的艾滋病宣传教育模式,推广安全套使用,加强性病医疗机构梅毒筛查和治疗。
Objective To understand the distribution characteristics and its associated factors of recent HIV infection among HIV/AIDS sentinel surveillance of men who have sex with men （MSM） in Shaanxi province from 2011 to 2015. Methods A total of 4609 samples were collected from MSM sentinel surveillance during 2011 -2015 for HIV antibody detection. As if the HIV antibody was positive,BED HIV capture enzyme immunoassay （BED） was employed to detect recent HIV infection. The recent HIV infection rate was estimated. Based on BED results and epidemiologic data, associated factors of recent infection were analyzed by using case - control study of 1：4 individual matching and conditional logistic regression. Results The annual recent HIV infection rates were 5.00% ,6.50% ,4.52% ,5.78% and 4.49% respectively during 2011 to 2015 in HIV/AIDS sentinel surveillance of MSM. 228 HIV - positive patients were diagnosed, and the proportion of recent HIV infection was 47. 4% （108/228）. It showed that the awareness of AIDS （OR = 6. 993,95% CI：1. 961 - 24. 508） and infected with syphilis （OR =3. 528,95% CI： 1. 605 - 7. 753 ） were risk factors related with HIV recent infection by using univariate conditional and multivariate conditional logistic regression analysis,and consistent use of condoms in the last 6 months （ OR = 0. 500,95% CI： 0. 302- 0. 827） was protective factor related with HIV recent infection. Conclusion The rate and proportion of recent infection of MSM HIV/AIDS sentinel surveillance in Shaanxi province were at a high level. Increasing publicity and education of AIDS,promoting consistent use of condoms and strengthening syphilis screening and treatments in STD medical institutions are necessary for reducing HIV incidence.
出处
《现代预防医学》
CAS
北大核心
2017年第1期160-162,166,共4页
Modern Preventive Medicine
基金
陕西省社会发展攻关项目(2013K12-21-02)
作者简介
张梦妍（1986-），女，硕士，中级，研究方向：艾滋病预防控制
通讯作者：常文辉，E—mall：changwenhui3@aliyun．com
