摘要
人参皂苷具有广泛的药理作用,对中枢神经系统、心血管系统、免疫系统、血液和造血系统等具有显著的药理作用。达玛烷型人参皂苷是人参属药材的主要药效成分,分为原人参二醇型和原人参三醇型2类。通过查阅近10年来国内外相关文献,对文献资料进行归纳和分析,分析人参皂苷Rb1,Rg1,Rc,Rd,Re等成分的药代动力学数据,发现达玛烷型人参皂苷的药代动力学过程与其结构密切相关。结构不同,2种类型的达玛烷型人参皂苷药代动力学过程存在显著差异。本文拟通过对原人参二醇型和原人参三醇型人参皂苷类成分的药物代谢动力学特征及二者的吸收、分布、代谢、排泄过程进行较为系统的梳理,为达玛烷型人参皂苷的深入研究提供参考。
Ginsenoside has a wide range of pharmacological effects. It has obvious pharmacological effects on the central nervous system,cardiovascular system,immune system,blood and hematopoietic system and so on. Dammarane-type ginsenoside is one of the main effective components of Panax ginseng,and it consists of protopanaxadiol type and protopanaxatriol type. Referring to domestic and foreign research reports of dammaranetype ginsenoside in recent decades, we compare and analyze the literature data in aspects of absorption,distribution,metabolism and excretion. The pharmacokinetic data of ginsenoside Rb1,Rg1,Rc,Rd and Re are summarized. The pharmacokinetic profile and feature of dammarane-type ginsenoside are closely related to its chemical structure. There are significant differences between two dammarane ginsenoside types. This paper reviews the pharmacokinetic characteristics of the two dammarane ginsenoside types,in order to provide references for their further studies.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第1期220-227,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81273654
81473579
81102879)
国家"重大新药创制"科技重大专项(2013ZX09103002-022)
作者简介
徐利云，在读硕士，从事中药药物代谢研究，Tel：18701003395，E-mail：xuliyun579@163．com
[通讯作者]杨志宏，副研究员，硕士生导师，从事药物代谢动力学及中药复方配伍机制研究，Tel：010-57833219，E-mail：zhyang@implad．ac．cn；
[通讯作者]孙晓波，研究员，博士生导师，从事中药药效物质基础与作用机制研究及新药研发，Tel：010-57833013，E-mail：xbsun@implad.ac.cn
