期刊文献+

常见肿瘤标志物的临床应用及进展 被引量:17

The clinical application and research progression of some canonical tumor biomarkers
原文传递
导出
摘要 早发现、早诊断是治愈肿瘤的关键。随着分子生物学技术的不断发展,肿瘤标志物检测在原发性肿瘤的发现、高危人群的筛查及肿瘤的发生发展等方面发挥着越来越重要的作用。目前临床上用于早期诊断、指导治疗及预后评估的成熟的肿瘤标志物相对有限,这些肿瘤标志物在临床应用上均存在一定的优势与局限性。而细胞增殖类标志物有望提高肿瘤的诊断检出率。 Early detection and diagnosis are the key steps in curing tumors .With the development of molecular biology technology , tumor biomarkers detection plays an increasingly important role in many aspects, such as looking for primary tumors , screening tumor susceptible persons and estimating the progression of various tumors .The number of frequently used tumor biomarkers in early detection , guiding treatment and estimating prognosis is limited .All these tumor biomarkers show their own advantages and certain limitations in clinical application .The tumor markers used in targeting cell proliferation are hopeful in promoting the rate of tumor detection .
作者 李林海
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2016年第12期995-998,共4页 Chinese Journal of Laboratory Medicine
关键词 肿瘤标志物 早期诊断 细胞增殖 Tumor biomarker Early detection Cell proliferation
作者简介 通信作者:李林海,电子信箱:mature303@126.com
  • 相关文献

参考文献5

二级参考文献30

  • 1朱海龙.CEA、AFP、CA125、CA15-3、CA19-9检测对恶性肿瘤的诊断价值探讨[J].现代医药卫生,2006,22(22):3422-3423. 被引量:23
  • 2邵丽佳,徐瑞龙,胡轶.血清CA125、CA199、CEA单检及联检对诊断卵巢癌的临床价值[J].放射免疫学杂志,2007,20(1):92-93. 被引量:25
  • 3Jacobs I J, Menon U. Progress and challenges in screening for early detection of ovarian cancer. Mol Cell Proteomics, 2004, 3 : 355- 366.
  • 4Bast RC Jr, Brewer M, Zou C, et al. Prevention and early detection of ovarian cancer: mission impossible? Recent Results Cancer Res, 2007, 174:91-100.
  • 5Morgan RJ Jr, Alvarez RD, Armstrong DK, et al. Ovarian cancer. Clinical practice guidelines in oncology. J Natl Compr Canc Netw, 2006, 4:912-939.
  • 6Rustin GJ, Bast RC Jr, Kelloff GJ, et al. Use of CA-125 in clinical trial evaluation of new therapeutic drugs for ovarian cancer. Clin Cancer Res, 2004, 10:3919-3926.
  • 7Hellstrom I, Raycraft J, Hayden-Ledbetter, et al. The HE4 (WFIXE) protein is a biomarker for ovarian carcinoma. Cancer Res, 2003, 63 : 3695 -3700.
  • 8Havrilesky LJ, Whitehead CM, Rubatt JM, et al. Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence. Gynecol Oncol, 2008, 110 : 374-382.
  • 9Moore RG, Brown AK, Miller MC, et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass. Gynecol Oncol, 2008, 108:402-408.
  • 10Moore RG, McMeekin DS, Brown AK, et al. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass. Gynecol Oncol, 2009, 112: 40-46.

共引文献61

同被引文献148

引证文献17

二级引证文献83

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部