摘要
目的探讨急性ST段抬高型心肌梗死(STEMI)中医证型与超敏C反应蛋白(hs-CRP)、N-末端脑钠肽前体(NT-pro BNP)的相关性。方法将316例STEMI患者及同期接受的60例健康体检者为研究对象。采用酶联免疫吸附法(ELISA)及电化学发光法(ECL)对STEMI患者及健康体检者hs-CRP、NT-pro BNP进行检测比较。将316例STEMI患者进行中医辨证分型,比较各亚组hs-CRP、NT-pro BNP,将所得数据进行统计,分析hs-CRP、NT-pro BNP与STEMI中医证型相关性。结果 STEMI患者hs-CRP、NT-pro BNP水平显著高于高于健康体检者(P<0.05),且STEMI患者各亚组均显著高于高于健康体检者(P<0.05)。STEMI患者各中医证型间hs-CRP、NT-pro BNP水平从高到低依次为:气虚血瘀型、痰瘀互阻型、寒凝心脉型、气阴两虚型、心肾阳虚型、心阳痹阻型。无法进行分型的20例患者hs-CRP、NT-pro BNP水平与痰瘀互阻型比较,无显著差异(P>0.05)。结论 STEMI中医证型与hs-CRP、NT-pro BNP密切相关,分析hs-CRP、NT-pro BNP有助于中医辨证客观化、揭示证的本质。
Objective To study the correlation between acute ST segment elevation myocardial infarction （STEMI） of TCM syndrome types and hypersensitive c -reactive protein （hs CRP） and N - terminal brain natriuretic peptide precursor （NT - proBNP）. Methods 316 patients with STEMI were selected as the study object, 60 cases of health physical examinees were selected as the research object. Enzyme -linked immunosorbent （ELISA）, electrochemical luminescence （ECL） and health physical examination were performed in pa- tients with STEMI hs - CRP, NT - proBNP for testing. 316 patients with STEMI were typed by TCM syndromes to compare various sub- groups of hs - CRP, NT - proBNP, analyse the statistical data to find out the hs - CRP, NT - proBNP correlation with STEMI TCM syndrome types. Results Hs - level of CRP, NT - proBNP were respectively （ 15.9 -4. 08） rag/L, （ 1723.5 -271.6） pg/L in SIEMI patients, and respectively （3.01 -0. 56） rag/L, （50. 3 -7. 58 ） pg/L in healthy physical examinees, significantly lower than those of STE- MI patients （ P 〈 0. 05 ） and the various subgroups of STEMI （P 〈 0. 05 ）. STEMI patients between different TCM syndrome types of hs - CRP, NT - proBNP levels from high to low in turn were： qi deficiency and blood stasis type 〉 transresistance phlegm and blood stasis type 〉 haemorrheological nature vein type 〉 heart qi and Yin deficiency type 〉 heart kidney Yang deficiency type 〉 heart Yang bizu type. Compared with transresistance phlegm and blood stasis type, the hs - CRP, NT - proBNP levels of the 20 patients unable to group was no significant difference （P 〉 0. 05）. Conclusion STEMI TCM syndrome types are closely associated with the hs CRP and NT - proBNP, the analysis of the hs - CRP, NT - proBNP is helpful to reveal the essence of the TCM syndrome objectively.
出处
《湖北中医药大学学报》
2016年第6期92-95,共4页
Journal of Hubei University of Chinese Medicine
基金
湖北省科技厅项目(项目编号:EK2014D260017001625)
关键词
ST段抬高型心肌梗死
中医证型
超敏C反应蛋白
N-末端脑钠肽前体
ST - elevation myocardial infarction
traditional Chinese medicine syndrome types
hypersensitive c - reactive protein
N - terminal brain natriuretic peptide precursor
作者简介
冷唯（1982-），女，湖北省武汉市第一医院初级护师，研究方向：护理。
