摘要
以天然大豆卵磷脂为主要材料,胆固醇、近红外量子点CdSeTe和超顺磁性Fe_3O_4粒子为附加材料,DO_X为包封的药物,制备了多功能复合载药脂质体。通过正交试验选取影响复合载药脂质体粒径和包封率的5个因素,即磷脂浓度、药脂比、超声时间、水化温度和Fe_3O_4量,每个因素选取4个水平进行优化实验。根据最优条件,采用薄膜分散发制备了多功能复合载药脂质体并对其粒径、磁性和荧光性质进行了测定。结果表明多功能复合载药脂质体粒径大约200nm、近似球形,且具有良好的近红外荧光性能和磁响应性能。
The multi-function composite doxorubicin-loading liposomes were prepared by the main material of nature soya lecithin, the additional material of cholesterol, the Fe3O4 nanoparticles and CdSeTe QDs as well as the drug of DOX. Taking the size and drug entrapment efficiency as index, orthogonal design of five factors four levels was taken to optimize the condition of multi-function composite doxorubicin-loading liposomes. And the five factors were the concentration of liposome, the ratio of drug to lipid, the ultrasound time, the hydration temperature and the quantity of Fe3O4. According to optimality condition, the multi-function Composite Doxorubicin-loading Liposomes were prepared by the thin-film dispersion method. And the size, the magnetism and the fluorescence properties of liposomes were detected. The results showed that the size of the multi-function composite doxorubicin-loading liposomes were 200nm and had good fluorescence and perfect magnetic responsibility.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2016年第B11期279-282,共4页
Chemical Industry and Engineering Progress
基金
国家自然科学基金项目(2097072)
作者简介
第一作者：李珍珍（1987-），女，博士研究生，主要研究方向为功能生物材料、药物载体等。
联系人：赵强，副教授。E-mail：Zhaoqiang@scu．edu．cn。
