摘要
目的比较冻融周期D5形成囊胚和非D5形成囊胚的临床妊娠结局,并分析囊胚形成的影响因素。方法选取2013年1月至2015年6月期间在我院行复苏周期囊胚移植的患者作为研究对象,根据冷冻时间,将其分成D5冷冻组和非D5冷冻组,其中D5冷冻组80个周期,非D5冷冻组78个周期,比较两组患者的一般资料、囊胚复苏率以及临床结局,并分析囊胚形成影响因素。结果D5冷冻组囊胚复苏率(99.3%)显著高于非D5冷冻组(95.5%)(P<0.05);D5冷冻组临床妊娠率、囊胚着床率均显著高于非D5冷冻组(P<0.05),D5冷冻组流产率显著低于非D5冷冻组(P<0.05);年龄<35岁组、BMI<24组、D3胚胎评分为I^II组、D3卵裂球为7~9组、碎片比例<25%组囊胚形成率显著高于年龄≥35岁组、BMI≥24组、D3胚胎评分为III^IV组、D3卵裂球非7~9组、碎片比例≥25%组(P<0.05)。结论 D5形成囊胚妊娠结局优于非D5形成囊胚,复苏周期优先移植D5形成囊胚可获得更高的临床妊娠率,年龄、BMI、D3胚胎评分、D3卵裂球数及碎片比例影响囊胚形成,临床治疗过程中应加以关注。
Objective To compare the clinical pregnancy outcome of blastocyst formation in different periods of freezing and thawing cycles and the factors affecting blastocyst formation of blastocyst.Methods During January 2013 to June 2015 in our hospital,according to the freezing time,the recovery blastocyst transfer cycles of patients were divided into D5 frozen group and non D5 freezing group.The general information,blastocyst recovery rate and clinical outcome of two groups of patients were compared and blastocyst formation factors were analyzed.Results The frozen blastocysts recovery rate of the D5group（99.3%）was significantly higher than that in non D5 frozen group（95.5%）（P〈0.05）;the clinical pregnancy rate and blastocyst implantation rate of D5 frozen group were significantly higher than those in non D5 frozen group（P〈0.05）,and abortion rate of D5 frozen group was significantly lower than that of non D5 frozen group（P〈0.05）;blastocyst formation rate of age〈35years old group,BMI 〈24 group,D3embryo score Ⅰ-Ⅱ group,D3 blastomeres for 7-9group,fragment ratio〈 25% group were significantly higher than that in ≥35years old group,BMI≥24groups,D3 embryo score Ⅲ and Ⅳ group,D3 blastomeres non 7-9group,fragment ratio≥25% group（P〈0.05）.Conclusion Pregnancy outcome of D5 blastocyst formation is better than non D5 blastocyst formation,and in recovery cycle,priority transplantation D5 blastocyst formation can obtain higher clinical pregnancy rate.Age,BMI,D3 embryo score,D3 blastomere number and percent fragmentation effect blastocyst formation,and it needs to be concerned in clinical treatment process.
出处
《青岛医药卫生》
2016年第6期405-408,共4页
Qingdao Medical Journal
关键词
冻融周期
囊胚
妊娠结局
影响因素
Freeze-thaw cycle
Blastocyst
Pregnancy outcome
Influencing factors
作者简介
仲纪祥,硕士研究生,从事辅助生殖技术工作
通讯作者：左阳花,E-mail：hazyh118@126.com
