摘要
为了优化白虎定喘口服液的煎煮工艺,以干膏量、绿原酸含量、黄芩苷含量为评价指标,以中药浸泡时间、加水量、煎煮时间、煎煮次数为影响因素,采用正交试验对其提取工艺进行多指标综合筛选。结果显示,煎煮次数对3个指标有显著影响,其他因素影响均不显著;优化的工艺条件为加15倍量水、浸泡0.5 h、每次煎煮0.5 h、煎煮3次。优选出的提取工艺稳定可行,有效成分提取率高,能保证制剂质量。
In order to optimize the decoction process of Baihu Dingchuan oral liquid,the extraction process were comprehensively screened by orthogonal test with dry paste volume,contents of chlorogenic acid and baicalin as the evaluation indexes and herbal medicine immersion time,amount of water,decocting time and decocting times as the influence factors. The results showed that decocting times had significant effects on the 3 indicators,and the influences of other factors were not significant. The optimized conditions were adding15- fold of water,soaking for 0. 5 hour,decocting for 3 times and 0. 5 hour each time. The optimized extraction process was stable and feasible with high active ingredient extraction rate,and it could guarantee the quality of preparation.
出处
《山东农业科学》
2016年第11期140-142,145,共4页
Shandong Agricultural Sciences
基金
国家公益性行业(农业)科研专项经费项目(201303040-10)
山东省农业重大应用技术创新项目[鲁财农(2016)36号]
山东省重点研发计划(2015GNC113004)
关键词
正交试验
提取工艺
干膏
绿原酸
黄芩苷
Orthogonal test
Extraction process
Dry paste
Chlorogenic acid
Baicalin
作者简介
作者简介：赵增成（1968-），男，副研究员，主要从事禽病防治及兽药研发S-作。E—mail：zhaozengcheng@sina．com
通讯作者：宋敏训（1963-），男，博士，研究员，研究方向：禽病防治及新兽药研究。E-mail：mxsong@aliyun．com
