摘要
目的通过联合检测血清CD64、降钙素原(PCT)与C-反应蛋白(CRP),探讨其在儿科发热患儿细菌感染的诊断价值,为临床抗生素使用提供指导。方法采用回顾性分析的方法分析2013年1月-2015年1月在该院因发热而住院的患儿,根据患儿的临床表现以及实验室诊断项目,分为细菌感染组,非细菌感染组,风湿性疾病组。体检健康的学龄前儿童为正常对照组。所有的患儿和正常对照组儿童在入院初24 h内分别采集静脉血检测CD64及PCT、CRP。结果将细菌感染组、非细菌感染组、风湿性疾病组分别与对照组进行比较,细菌感染组CD64值(4.09±0.46)高于对照组(1.16±0.07),差异有统计学意义(t=2.986,P<0.05),非细菌感染组(1.27±0.14)、风湿性疾病组(1.19±0.07),CD64值与对照组相比较差异无统计学意义(t值分别为1.552、1.234,均P>0.05)。细菌感染组、风湿性疾病组PCT值、CRP值高于对照组,差异有统计学意义(t值分别为3.215、2.786、3.016、8.221,均P<0.05),但细菌感染组PCT值高于风湿性疾病组,差异有统计学意义(t=2.985,P<0.05),风湿性疾病组CRP最高,与其余各组比较差异有统计学意义(t值分别为6.254、8.314、8.221,均P<0.05)。CD64诊断细菌感染的敏感度为88.75%,为3个指标中最高。结论 CD64、PCT与CRP均可作为早期诊断儿科细菌感染性疾病的指标,CD64作为细菌感染性指标的诊断价值最大。
Objective To explore the diagnostic value of serum CD64, procalcitonin （PCT）, and C-reactive protein （CRP） for bacterial infection of children with fever in Department of Pediatrics by joint detection of CD64, PCT, and CRP levels, provide guidance for antibiotic use. Methods The hospitalized children with fever from January 2013 to January 2015 were analyzed retrospectively, then they were divided into bacterial infection group, non-bacterial infection group, and rheumatic disease group according to clinical manifestations and laboratory tests. The preschool children after healthy physical examination were selected as control group. CD64, PCT, and CRP levels in peripheral blood within 24 hours after admission in the four groups were detected seperately. Results CD64 level in bacterial infection group was （4. 09±0.46）, which was statistically significantly higher than that in control group （1.16±0.07） （t=2. 986, P〈0. 05） ; CD64 levels in non-bacterial infection group and rheumatic disease group were （1.27±0. 14） and （1.19±0.07）, respectively, compared with control group, there was no statistically significant difference （t = 1. 552, P〉0. 05 ; t = 1. 234, P〉0. 05） . The levels of PCT and CRP in bacterial infection group and rheumatic disease group were statistically significantly higher than those in control group （ t = 3. 215, 2. 786, 3.016, 8. 221, P〈0.05 ） ; the level of PCT in bacterial infection group was statistically significantly higher than that in rheumatic disease group （t = 2. 985, P〈0. 05） . The level of CRP in rheumatic disease group was the t±ighest, compared with other groups, there were statistically significant differences （ t = 6. 254, 8. 314, 8. 221, P〈0. 05 ） . The sensitivity of CD64 in diagnosis of bacterial infection was 88.75%, which was the highest one among the three indexes. Conclusion CD64, PCT, and CRP can be used as the indexes of early diagnosis of bacterial infection in Department of Pediatrics, the diagnostic value of CD64 is the highest among the three indexes.
出处
《中国妇幼保健》
CAS
2016年第23期5024-5027,共4页
Maternal and Child Health Care of China
基金
南京市卫生局课题(YKK14095)
关键词
CD64
C-反应蛋白
降钙素原
感染性疾病
儿科
CD64
C-reactive protein
Procalcitonin
Infectious disease
Department of pediatrics
作者简介
通讯作者：张莉，E-mail：lily6116@163．com
