摘要
目的：观察多发性硬化（MS）患者血及脑脊液中分泌型磷脂酶A2（sPLA2）和溶血磷脂酸（LPA）水平的变化及相关性。方法选取21例急性期MS患者（急性期MS组），20例缓解期MS患者（缓解期MS组），21例非炎性、血管性神经系统疾病患者（对照组），测定三组血sPLA2、血浆LPA及脑脊液sPLA2、LPA水平，并进行比较。结果急性期MS组血及脑脊液sPLA2、LPA水平均显著高于缓解期MS组和对照组（P＜0.01）。急性期MS组经治疗后血及脑脊液sPLA2、LPA水平显著低于治疗前（P＜0.01）。急性期MS组治疗前后血sPLA2与LPA水平存在相关性（r＝0.962，P＝0.000；r＝0.848，P＝0.000）；急性期MS组治疗前后脑脊液sPLA2与LPA水平存在相关性（r＝0.968，P＝0.000；r＝0.850，P＝0.000）。结论血及脑脊液sPLA2、LPA水平可作为评估MS患者疾病活动性的炎性标志物。
Objective To explore the levels of secretory phospholipase A2 （sPLA2） and lysophosphatidic acid （LPA） in blood and cerebrospinal fluid of patients with multiple sclerosis （MS）, and to explore the relationship between the levels of these inflammatory biomarkers and disease activity of MS. Methods Blood samples were collected from 21 MS patients of acute period （acute period of MS group）, 20 MS patients of remitting period （remitting period of MS group） and 21 patients with non inflammatory and vascular neurologic disease （control group）. The levels of sPLA2 and LPA in blood and cerebrospinal fluid were measured and compared. Results The levels of sPLA2 and LPA in blood and cerebrospinal fluid before treatment in acute period of MS group were significantly higher than those in remitting period of MS group （P〈0.01） and in control group （P〈0.01）. The levels of sPLA2 and LPA in blood and cerebrospinal fluid after treatment were significantly lower than those before treatment in acute period of MS group （P〈0.01）. The levels of sPLA2 and LPA in blood before and after treatment had correlations in acute period of MS group （r=0.962, P=0.000;r=0.848, P=0.000）. The levels of sPLA2 and LPA in cerebrospinal fluid before and after treatment had correlations in the acute period group （r=0.968, P=0.000;r=0.850, P=0.000）. Conclusions The levels of sPLA2 and LPA in blood and cerebrospinal fluid may be used as inflammatory biomarkers for disease activity in MS patients.
作者
蒋东晓
连艳芬
Jiang Dongxiao Lian Yanfen.(Department of Neruology, Weihai Wendong Central Hospital Affiliated of Weifang Medical College, Shandong Weihai 264400, Chin)
出处
《中国医师进修杂志》
2016年第11期961-964,共4页
Chinese Journal of Postgraduates of Medicine
关键词
多发性硬化
分泌型磷脂酶A2
溶血磷脂酸
Multiple sclerosis
Secretory phospholipase A2
Lysophosphatidic acid
作者简介
通信作者：蒋东晓，Email：jdx_jiang@163．com
