老年高血压患者动态动脉硬化指数与左心室质量指数的相关性被引量：21

Association between ambulatory arterial stiffness index with left ventricular mass index in the elderly hypertensive patients

原文传递

导出

摘要目的探讨老年原发性高血压患者动态动脉硬化指数（AASI）与左心室质量指数（LVMI）的相关性.方法入选2012年1月至2014年12月北京大学第一医院老年内科心血管病房住院的老年（≥60岁）原发性高血压患者332例.记录患者24 h动态血压,并计算AASI.通过超声心动图检查计算LVMI.根据AASI中位数将患者分为＜中位数组（低AASI组）和≥中位数组（高AASI组）.采用Pearson相关分析分析变量间的相关性,采用多因素线性回归分析AASI与LVMI的相关性.结果高AASI组患者LVMI高于低AASI组[（115.91±21.36） g/m2比（104.11 ±17.24）g/m2,P=0.008].Pearson相关分析显示AASI和24 h脉压与LVMI呈正相关（r=0.332,P＜0.001;r =0.169,P=0.002）.多因素线性回归分析结果显示AASI（B=44.48,P＜0.001）、低密度脂蛋白胆固醇（B=-5.97,P＜0.001）和尿酸（β=0.02,P=0.045）是LVMI的主要影响因素.结论 AASI与LVMI独立相关,可考虑将AASI作为住院老年高血压患者左心室肥厚的预测因子. Objective To investigate the relationship between ambulatory arterial stiffness index （AASI） and left ventricular mass index （LVMI） in the elderly hypertensive patients.Methods This study population consisted of 332 elderly hypertensive patients,who hospitalized in our department from January 2012 to December 2014.AASI was calculated from 24 h ambulatory BP monitoring recordings and LVMI from echocardiography examination.According to the median value of AASI,patients were divided to less than the AASI median group （low AASI group） and equal to or above the AASI median group （high AASI group）.Differences between two groups were evaluated using the Student＇s t-test and Chi-square test.Univariate association was assessed by the Pearson correlation analyses.Multivariate linear regression models were performed to analyze the correlation between AASI and LVMI.Results LVMI was significantly higher in high AASI group compared with low AASI group （（115.91 ±21.36） g/m2 vs.（104.11 ± 17.24） g/m2,P =0.008）.Pearson correlation analyses showed that AASI and 24 h pulse pressure were positively correlated to LVMI （r =0.332,P ＜ 0.001;r =0.169,P =0.002）.In multivariate linear regression model,AASI（β =44.48,P＜0.001）,LDL-C（β =-5.97,P＜0.001） and UA （β =0.02,P =0.045） showed significant association with LVMI.Conclusion AASI independently associated with LVMI,and AASI might be one predictor of left ventricular hypertrophy in hospitalized elderly hypertensive patients.

作者陈荟荷孙燕淑刘梅林

机构地区北京大学第一医院老年科

出处《中华心血管病杂志》 CAS CSCD 北大核心 2016年第9期750-753,共4页 Chinese Journal of Cardiology

基金国家科技支撑计划（2012BA137B00）

关键词高血压老年人动脉粥样硬化心脏扩大 Hypertension Aged Atherosclerosis Cardiomegaly

分类号 R544.1 [医药卫生—心血管疾病]

作者简介通信作者：孙燕淑，Email：susanys63@sina．com

引文网络
相关文献

参考文献4

1Yong FENG,Hai Ming ZHANG,Lei LIU,Yong Hui WANG,Zhao Xiong LIANG,Qing Xiang GUO.Theoretical Studies on the Conformation of mono-6-O-p-nitrobenzoyl-β-cyclodextrin in Aqueous Solution[J].Chinese Chemical Letters,2001,12(7):637-640. 被引量：2
2吴琪,刘忠,汪东良.高血压患者动态动脉硬化指数与左室肥厚的相关性[J].中国现代医生,2011,49(3):20-21. 被引量：9
3李燕,朱鼎良,王继光.动态的动脉硬化指数[J].中华心血管病杂志,2009,37(2):189-192. 被引量：18
4中国高血压防治指南2010[J].中华心血管病杂志,2011,39(7):579-616. 被引量：4581

二级参考文献32

1Laurent S, Cockcroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J, 2006, 27: 2588-2605.
2Mancia G, De Backer G, Dominiczak A, et al. 2007 ESH-ESC pratice guidelines for the management of arterial hypertension: ESH-ESC task force on the management of arterial hypertension. J Hypertens, 2007, 25: 1751-1762.
3Li Y, Wang JG, Dolan E, et al. Ambulatory arterial stiffness index derived from 24-hour ambulatory blood pressure monitoring. Hypertension, 2006, 47 : 359-364.
4Dechering DG, Adiyaman A, van der Steen M, et al. Interstudy variability in the ambulatory arterial stiffness index. Hypertension,2007, 50: e65.
5Gavish B, Ben-Dov IZ, Bursztyn M. Ambulatory Arterial Stiffness Index is not a specific marker of reduced arterial compliance. Hypertension, 2007, 50: e18.
6Gavish B, Ben-Dov IZ, Bursztyn M. Linear relationship between systolic and diastolic blood pressure monitored over 24 h: assessment and correlates. J Hypertens. 2008, 26: 199-209.
7Dolan E, Thijs L, Li Y, et al. Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study. Hypertension, 2006, 47: 365-370.
8Chamontin B. The best of hypertension in 2006. Arch Mal Coeur Vaiss, 2007, 100: 41-45.
9Dolan E, Li Y, Thijs L, et al. Ambulatory arterial stiffness index: rationale and methodology. Blood Press Monit, 2006, 11: 103- 105.
10Li Y, Dolan E, Wang JG, et al. Ambulatory arterial stiffness index: determinants and outeome. Blood Press Monit, 2006, 11 : 107-110.