摘要
目的探讨幽门螺杆菌(Hp)感染与超声检测颈动脉粥样硬化程度及血清基质金属蛋白-9(MMP-9)、内脂素的相关性,为其临床研究提供参考依据。方法选择2015年1月-2016年5月132例Hp感染检测阳性的患者为观察组,同期选择148例Hp感染检测阴性的患者为对照组,所有受试者均行颈部血管彩超检查,并对颈动脉内中膜厚度(IMT)进行测量,采用酶联免疫吸附法测定MMP-9及内脂素。结果观察组患者IMT为(1.42±0.61)mm,明显高于对照组(0.64±0.40)mm,差异有统计学意义(P<0.05),观察组患者斑块形成94例(71.2%)明显高于对照组80例(54.1%),差异有统计学意义(P<0.05);观察组患者软斑例数最高,其次为混合斑,硬斑最少;对照组硬斑例数最高,其次为混合斑,软斑数最少,差异有统计学意义(P<0.05);观察组有斑块及无斑块患者MMP-9及内脂素水平均高于对照组,差异有统计学意义(P<0.05),观察组与对照组有斑块患者MMP-9及内脂素水平均高于无斑块患者,差异有统计学意义(P<0.05)。结论 Hp感染可以促进颈动脉粥样硬化的发生,与软斑关系更密切,且可以促进MMP-9、内脂素水平升高,加重颈动脉粥样硬化程度。
OBJECTIVE To explore the relationship between Helicobacter pylori （Hp） infection and carotid athero‐sclerosis degree detected by ultrasound ,serum matrix metalloprotein‐9 （MMP‐9） ,and visfatin so as to provide guidance for clinical study .METHODS A total of 132 patients who were detected positive for Hp infection from Jan 2015 to May 2016 were chosen as the observation group ,meanwhile ,148 patients who were detected negative for Hp infection were set as the control group .All of the participants received carotid color Doppler ultrasound exami‐nation ,the carotid intima‐media thickness （IMT） was measured ,and the MMP‐9 and visfatin were determined by using enzyme‐linked immunosorbent assay .RESULTS The IMT of the observation group was （1 .42 ± 0 .61） mm ,significantly higher than （0 .64 ± 0 .40）mm of the control group（P〈0 .05） .The proportion of the patients with plaque formation of the observation group was 71 .2% （94 cases） ,significantly higher than 54 .1% （80 ca‐ses） （P〈0 .05） .In the observation group ,the proportion of the patients with soft plaque was the highest ,fol‐lowed by the proportion of the patients with mixed plaque ,the proportion of the patients with hard plaque the low‐est .In the control group ,the proportion of the patients with hard plaque was the highest ,followed by the propor‐tion of the patients with mixed plaque ,the proportion of the patients with soft plaque the lowest ,and there was significant difference （P〈0 .05） .The levels of MMP‐9 and visfatin of the patients with plaque or without plaque were significantly higher in the observation group than in the control group （P〈0 .05）;the levels of MMP‐9 and visfatin of the patients with plaque of the observation group and the control group were significantil higher than those of the patients without plaque （P〈0 .05） .CONCLUSION The Hp infection can promote the occurrence of carotid atherosclerosis ,lead to the elevation of levels of MMP‐9 and visfatin ,and aggravate the degree of carotid atherosclerosis ,it has closer relationship with the soft plaque .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第22期5141-5143,共3页
Chinese Journal of Nosocomiology
基金
河南省医学科技攻关项目(142122310047)
关键词
幽门螺杆菌
超声
颈动脉粥样硬化
基质金属蛋白
内脂素
Helicobacter pylori
Ultrasound
Carotid atherosclerosis
Matrix metalloprotein
Visfatin
作者简介
通信作者：卢学峰，E-mail：baiqiuen1105@sina．com.
