摘要
目的探讨乳腺癌术后常规化疗辅以中药治疗对患者远期转移复发率和生活质量的影响。方法按治疗方法不同将144例女性乳腺癌术后患者分为观察组86例和对照组58例。对照组给予环磷酰胺+吡柔比星+5-氟尿嘧啶化疗方案治疗,观察组在此基础上配合自拟扶正祛邪解毒方治疗,2组均以6个月为1个疗程。比较2组5年复发转移率及治疗后生活质量评分、中医证候评分、T淋巴细胞亚群(CD4+、CD8+、CD4+/CD8+)的变化。结果随访期间,观察组5年转移复发率显著低于对照组(P<0.05)。治疗后,2组SF-36量表8个维度的生活质量评分均明显高于治疗前(P均<0.05),且观察组各项评分均显著高于对照组(P均<0.05);2组中医证候积分均较治疗前降低(P均<0.05),且观察组各项评分均显著低于对照组(P均<0.05)。对照组治疗后T淋巴细胞亚群CD4+和CD4+/CD8+均较同组治疗前显著降低(P均<0.05),CD8+较同组治疗前显著升高(P<0.05),观察组治疗后CD4+和CD4+/CD8+均显著高于对照组(P均<0.05),CD8+显著低于对照组(P<0.05)。结论乳腺癌术后常规化疗辅以中药治疗,可降低患者远期转移复发率,提高生存质量,改善临床症状,值得临床推广应用。
Objective It is to investigate the influence of postoperative conventional chemotherapy combined with traditional Chinese medicine treatment on long-term metastasis and recurrence rate and quality of life of patients with breast cancer.Methods 144 cases of female breast cancer patients were divided into observation group（86 cases） and control group（58 cases） according to different treatment methods. The patients were treated with cyclophosphamide plus pirarubicin and 5- fluorouracil chemotherapy treatment in control group,and were treated with Fuzheng Quxie Jiedu Decoction（ FZQXJD） on the basis of control group in the observation group,6 months for 1 courses. The 5 years metastasis and recurrence rate,and the changes of quality of life score,TCM syndrome score,T lymphocyte subsets（ CD4＋,CD8＋,CD4＋/ CD8＋） after treatment of the two groups were compared. Results During the follow-up period,the 5 years recurrence rate of the observation group was significantly lower than the control group（ P 0. 05）. After treatment,the quality of life score of SF- 36 scale with 8 dimensions were significantly higher than those before treatment in both groups（ all P 0. 05）,and all the scores of the observation group were significantly higher than those of the control group（ all P 0. 05）; the TCM syndrome integral were significantly decreased in both groups than before treatment（ all P 0. 05）,and the scores of the observation group were significantly lower than those of the control group（ all P 0. 05）. After treatment,the level of CD4＋and CD4＋/ CD8＋were significantly decreased（ all P 0. 05）,and CD8＋was significantly increased（ P 0. 05） in the control group; while the level of CD4＋and CD4＋/ CD8＋were significantly higher than the control group（ all P 0. 05）,and CD8＋was significantly lower than the control group（ P 0. 05）. Conclusion Postoperative conventional chemotherapy combined with traditional Chinese medicine therapy for breast cancer patients can reduce the recurrence rate,improve the quality of life,relieve the clinical symptoms,it is worthy of clinical application.
出处
《现代中西医结合杂志》
CAS
2016年第33期3670-3672,3715,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
乳腺癌
化疗
中药
免疫功能
转移
复发
生活质量
breast cancer
chemotherapy
traditional Chinese medicine
immune function
metastasis
recurrence
quality of life
