摘要
目的探讨吸入布地奈德与静脉注射甲泼尼龙治疗慢性阻塞性肺疾病急性加重期(AECOPD)的疗效。方法随机抽取2012年6月至2015年3月收治的91例AECOPD患者的临床资料。按照随机数字表法将患者分为实验组(46例)和对照组(45例)。患者均采取一般处理,常规应用吸氧、支气管扩张剂、抗生素抗感染等治疗。在此基础上,对照组患者采取静脉注射甲泼尼龙治疗,实验组患者采取吸入布地奈德治疗,观察两组患者血气指标变化情况、肺功能变化情况、不良反应发生情况。结果实验组患者治疗后氧分压(PO2)、1秒用力呼气容积占预计值百分比(FEV1%)均高于治疗前和对照组,差异有统计学意义(P<0.05);实验组患者治疗后二氧化碳分压(PCO2)低于治疗前和对照组,差异有统计学意义(P<0.05)。对照组患者治疗后PO2、FEV1%均高于治疗前,差异有统计学意义(P<0.05);对照组患者治疗后PCO2低于治疗前,差异有统计学意义(P<0.05)。两组患者均未发生严重不良反应。结论吸入布地奈德与静脉注射甲泼尼龙治疗慢性阻塞性肺疾病急性加重期效果较好,患者血气指标、肺功能均得到较好改善,无严重不良反应,临床应用价值较高。
Objective To investigate the curative effects of inhaling budesonide and intravenous injection of prednisolone on chronic obstructive pulmonary disease in acute exacerbation period（ AECOPD）. Methods The clinical data of 91 patients with AECOPD from June 2012 to March 2015 were random selected. The patients were divided into the experiment group（ 46 cases）and control group（ 45 cases） according to random number table method. The patients took general processing,and the conventional application of oxygen,bronchodilator,treatment such as antibiotic resistance to infection. On this basis,the patients in control group adopted intravenous injection of prednisolone treatment,and the treatment group were treated with inhaled budesonide. Blood gas index,pulmonary function changes,the changes of adverse reactions of the two groups were observed.Results The PO2 and FEV1 % after treatment of the experiment group were higher than those of before treatment and the control group,and the differences were significant（ P〈0. 05）; PCO2 after treatment of the experiment group was lower than that before treatment and the control group,the difference was significant（ P〈0. 05）. The PO2,FEV1 % after treatment of the control group were higher than those before treatment,the difference was significant（ P〈0. 05）; while PCO2 after treatment of the control group was lower than that before treatment,and the difference was significant（ P〈0. 05）. Patients of the two groups had no serious adverse reactions. Conclusion The curative effects of inhaling budesonide and intravenous injection of prednisolone on chronic obstructive pulmonary disease in acute exacerbation period is good; the blood gas index,pulmonary function of patients can be improved,no serious adverse reactions,and has higher clinical value.
出处
《临床医学》
CAS
2016年第10期17-18,共2页
Clinical Medicine
关键词
布地奈德
甲泼尼龙
慢性阻塞性肺疾病
急性加重期
疗效
Budesonide
Methyl prednisolone
Chronic obstructive pulmonary disease
Acute exacerbation period
Curative effect
