摘要
目的探讨OPG、RANK和RANKL水平的变化在骨质疏松性骨折愈合过程中的意义。方法随机选择在本院住院治疗的骨质疏松性骨折病例228例为病例组,同期因其他外伤入院者106人为对照组。采用ELISA方法检测血清OPG、RANK和RANKL的水平。比较2组OPG、RANK和RANKL的水平及OPG/RANKL比值的变化。结果骨折后病例组OPG水平上升,至伤后1周达到最高(206.64±57.22)pg/m L,显著高于对照组(P<0.05),伤后2周仍维持在较高的水平。病例组RANK和RANKL在伤后第3天达最高,分别为(108.45±20.45)pg/m L和(107.45±32.67)pg/m L,均显著高于对照组(P<0.05),然后逐步下降。病例组OPG/RANKL比值在伤后呈升高趋势,至伤后2周达到高峰(2.13±0.02),伤后第3天、1周、2周、4周的比值均显著高于伤后第1天(P<0.05)。OPG与RANKL呈负相关关系(P<0.05)。结论 OPG/RANK/RANKL系统对骨质疏松性骨折术后的愈合有较重要的作用。
Objective To explore the significance of changes of OPG,RANK and RANKL in the healing process of osteoporotic fracture. Methods A total of 228 patients with osteoporotic fracture were chosen as case group,and 106 hospitalized patients with trauma in the same period were chosen as control group. The levels of OPG,RANK and RANKL in serum were tested by ELISA,and the change of OPG,RANK,RANKL and ratio of OPG to RANKL were compared. Results The level of OPG in case group increased after fracture, and reached the highest level（ 206. 64 ±57. 22） pg / m Lat 1 week after fracture,and was higher than that of control group（ P〈0. 05）. The OPG still maintained at the relatively high level at 2 weeks after fracture. The RANK（ 108. 45 ±20. 45） pg / m L and RANKL（ 107. 45 ± 32. 67） pg / m L of case group reached the highest level at 3days after fracture,both were significantly higher than those of control group（ P〈0. 05）,and then decreased. The ratio of OPG / RANKL rose after fracture and reached the highest value（ 2. 13 ±0. 02） at 2 weeks after fracture. The ratios at 3 days,1,2 and 4 week after fracture were all higher than the ratio at 1 day after fracture（ P〈0. 05）. The OPG was negatively correlated with RANKL（ P〈0. 05）. Conclusion The system of OPG/RANK/RANKL has an important role in the healing process of osteoporotic fracture.
出处
《实用临床医药杂志》
CAS
2016年第19期51-54,共4页
Journal of Clinical Medicine in Practice
