摘要
西班牙学者Cajal首次发现并描述了Cajal间质细胞（ICC），最近几十年ICC的研究进展迅速。胃肠道ICC产生慢波活动，协调起搏活动和慢波传播，传导肠神经系统与平滑肌细胞间的神经信号，亦是胃肠道肌肉的牵张感受器。ICC的形态、结构、数目的改变与多种胃肠道疾病相关。c-kit表达对ICC具有重要作用，调控SCF/c-kit信号系统能导致ICC形态的改变。胃肠道ICC上有胃动素受体表达，胃动素激动剂通过ICC上胃动素受体促进胃肠道平滑肌运动；ICC可以进行分离和传代。
Cajal initially identified interstitial cells of Cajal（ICC）. In recent decades the researches on ICC were rapid. It is known to all that ICC contribute to several important functions in the gastrointestinal tract including： generation of electrical slow wave activity, coordination of pacemaker activity and active propagation of slow waves, transduction of motor neural inputs from the enteric nervous system, and mechanosensation to stretch of gastrointestinal muscles. The changes of morphology, distribution, number, phenotypic in ICC might affect on the gastrointestinal func- tion, and might lead to gastrointestinal disease. Expression of c - kit has an important role in the ICC. Regulation of SCF/c - kit signaling system can lead to changes in morphology of ICC. In the gastrointestinal tract, motilin receptor ex- pression in the ICC. The promotion of motilin receptor agonist to intestinal tract were mediated by ICC. ICC can be iso- lated and subcuhured.
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2016年第19期1506-1508,共3页
Chinese Journal of Applied Clinical Pediatrics
关键词
CAJAL间质细胞
胃肠动力
先天性巨结肠
胃动素受体
Interstitial cells of Cajal
Gastrointestinal motility
Hirschsprung＇s disease
Motilin receptor
作者简介
通信作者：王宝西，Email：ekwbx1960@163．com
