摘要
目的:制备洛索洛芬钠缓释微丸,并考察其体外释药行为。方法:采用挤出滚圆法制备洛索洛芬钠载药丸芯,再用Eudragit RL 30D和Eudragit RS 30D进行包衣,制成洛索洛芬钠缓释微丸,并考察缓释微丸的体外释药行为。结果:以Eudragit RL 30D和Eudragit RS 30D的比例为20∶80作为洛索洛芬钠载药丸芯的缓释包衣材料,包衣增重为20%,增塑剂用量为10%,滑石粉用量为45%时,制备的洛索洛芬钠缓释微丸在12h内能够平稳释药且释药完全。结论:制备的洛索洛芬钠缓释微丸释药行为较好,有望应用于工业生产。
Objective： To prepare loxoprofen sodium sustained release pellets, and investigate the in vitro drug release behavior. Methods： Loxoprofen sodium loaded pellets were prepared by extrusion-spheronization technology, and the sustained release pellets were prepared with Eudragit RL 30D and Eudragit RS 30D as the sustained release coating film materials. The drug release behavior of loxoprofen sodium sustained release pellets in vitro was studied. Results ： Eudragit RL 30D and Eudragit RS 30D with the ratio of 20 ： 80 was used as the sustained release coating film materials, the coating weight was 20%, the plasticizer content was 10%, and the content of talc was 45%. The in vitro release of loxoprofen sodium from the sustained release pellets was steady and entire in 12 h. Conclusion： The release behavior of loxoprofen sodium sustained release pellets is quite satisfactory. And the preparation technology may be used in the industrial production.
出处
《中国药师》
CAS
2016年第10期1885-1888,共4页
China Pharmacist
关键词
洛索洛芬钠
缓释微丸
体外释药
挤出滚圆法
Loxoprofen sodium
Sustained release pellets
In vitro drug release
Extrusion-spheronization technology
作者简介
通讯作者：于佳Tel：17709875919E—mail：songlidr@163．com
