摘要
丝裂原活化蛋白激酶(MAPK)信号通路的异常活化与肝癌的发生、发展、转移密切相关。介绍了MAPK通路蛋白在肝癌中的表达及其在肝癌增殖、分化、转移中的作用,阐述了MAPK信号通路在肝癌治疗及预后评价中的价值。认为MAPK信号通路在肝癌的发生发展及治疗中发挥非常重要的作用,是肝癌治疗及预后评价的潜在分子靶点。
Abnormal activation of the mitogen- activated protein kinase（ MAPK） signaling pathway is closely associated with the development,progression,and metastasis of liver cancer. This article introduces the expression of MAPK proteins in liver cancer and its role in the proliferation,differentiation,and metastasis of liver cancer,and elaborates on the value of the MAPK signaling pathway in the treatment and prognostic evaluation of liver cancer. It is pointed out that the MAPK signaling pathway plays an important role in the development/progression and treatment of liver cancer and is a potential molecular target for the treatment and prognostic evaluation of liver cancer.
出处
《临床肝胆病杂志》
CAS
2016年第9期1810-1813,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金资助项目(81471720)
国家自然科学基金面上项目(31371425)
辽宁省自然科学基金(2013023056)
盛京自由研究者基金(200802)
作者简介
次旦旺久（1984-），男，在读博士，主要从事肝脏疾病诊断及治疗方面的研究。
通信作者：赵相轩，电子信箱：zhaoxx@sj-hospital．org。
通信作者：王晓明，电子信箱：wangxml@sj-hospital．org
