摘要
母婴传播是乙型肝炎病毒(hepatitis B virus,H B V)感染的主要传播方式,阻断母婴传播是控制乙型肝炎流行的重要手段.然而目前妊娠期乙型肝炎管理尚存在诸多问题,如缺乏有关母婴乙型肝炎诊治的统一指南策略等.尽管目前我国对新生儿采取注射乙型肝炎免疫球蛋白和乙型肝炎疫苗的主-被动联合免疫来阻断母婴传播,但仍有新生儿感染HBV.近年来随着抗HBV药物的使用,人们积累了核苷类药物阻断乙型肝炎母婴传播的成功经验.本文系统总结分析了目前用于阻断HBV母婴传播的各种方案,旨在使母婴传播的阻断策略更加规范有效.
Mother-to-child transmission is the main way of hepatitis B virus （HBV） infection. Thus, blocking mother-to-child transmission is an important means to control the epidemic of HBV. However, the management of pregnant women with HBV still has many problems, such as the lack of uniform guidelines on the treatment. Although passive-active immunoprophylaxis, including hepatitis B immunoglobulin and hepatitis B virus vaccine, is widely used at birth to interrupt HBV transmission, mother-to- child transmission of HBV still occurs in some infants. In recent years nucleoside analog has been widely used in clinical practice. This paper summarizes and analyzes a variety of programs of blocking mother-to-child transmission, aiming to make strategies to prevent mother-to-child transmission of HBV more standardized and effective.
出处
《世界华人消化杂志》
CAS
2016年第23期3439-3444,共6页
World Chinese Journal of Digestology
基金
青岛市城阳区科技局计划基金资助项目
No.2013016~~
关键词
乙型肝炎病毒
母婴传播
抗病毒药物
Hepatitis B virus
Mother-to-childtransmission
Antiviral agents
作者简介
孙维会，副教授，副主任医师．主要从事传染病临床与教学研究通讯作者：孙维会，副教授，副主任医师，硕士生导师，266108，山东省青岛市城阳区长城路600号，青岛市城阳人民医院感染性疾病科．sunty2009@l26.com电话：0532-80657102
