摘要
目的观察及研究高压氧治疗对新生儿缺氧缺血性脑病氧化应激状态及脑血流的影响。方法选取56例缺氧缺血性脑病新生儿为研究对象,将其随机分为对照组28例和观察组28例,对照组新生儿进行常规缺氧缺血性脑病治疗,观察组则在对照组的基础上加用高压氧治疗,然后将2组新生儿治疗前和治疗后3、7及14 d的氧化应激状态相关血清指标及大脑中动脉、前动脉血流指标进行比较。结果治疗后3、7及14 d,观察组的氧化应激状态相关血清指标及大脑中动脉、前动脉血流指标均显著好于对照组(P<0.05)。结论高压氧治疗可有效改善缺氧缺血性脑病新生儿的氧化应激状态及脑血流状态。
Objective To observe and study the influence of hyperbaric oxygenation on the oxidative stress state and cerebral blood flow of newborns with hypoxie-ischemic encephalopathy. Methods A total of 56 newborns with hypoxie-ischemic eucephalopathy were selected and randomly divided into control group and observation group, 28 cases in each group. The control group was trea- ted with conventional treatment for hypoxie-ischemic encephalopathy, while the observation group was treated with hyperbaric oxygenation on the basis of control group. The oxidative stress state related se- rum indexes and blood flow indexes of middle cerebral artery and anterior cerebral artery of two groups before the treatment and at 3rd, 7th and 14th days after the treatment were compared. Results The oxidative stress state related serum indexes and blood flow indexes of middle cerebral artery and ante- rior cerebral artery in observation group at 3rd, 7th and 14th days after the treatment were significantly better than those in control group （ P 〈 0.05 ）. Conclusion The hyperbaric oxygenation can effec- tively improve the oxidative stress state and cerebral blood flow state of newborns with hypoxie-ische- mic encephalopathy.
出处
《实用临床医药杂志》
CAS
2016年第17期85-87,共3页
Journal of Clinical Medicine in Practice
基金
陕西省卫生厅资助基金(sx2891223)
关键词
高压氧治疗
新生儿缺氧缺血性脑病
氧化应激状态
脑血流
hyperbaric oxygenation
newborns with hypoxie-ischemic encephalopathy
ox-idative stress state
cerebral blood flow
