摘要
基因表达调控是动物被毛生长和发育的决定性因素。microRNA作为一种新发现的基因调控元件,在多种哺乳动物皮肤及毛囊中均有表达,并在转录后水平调节皮肤和毛发的生长和发育过程。从microRNA水平上解析绵羊、山羊及羊驼等被毛生长特点及发生机理,为提高毛用型经济动物的毛发品质和产量提供新的思路,同时也为更深入地研究皮肤组织中microRNA的功能提供更多的理论依据。作者主要针对目前已报道的在绵羊、山羊及羊驼等哺乳动物皮肤及毛囊发育中microRNA的调控作用进行综述。
The regulation of gene expression is a decisive factor in the growth and development of animal hair.microRNA,as a newly discovered gene regulatory element,is expressed in many kinds of mammalian skin and hair follicles,regulating the growth and development of skin and hair in post-transcriptional level.Analysising the characteristics and mechanisms of hair growth in sheep,goats,alpacas and other mammals,in microRNA level,may provide the new ideas in improving economic animal hair quality and yielding,and the more in-depth research the function of microRNA in skin tissue.In the present review,we focus on the regulatory role of microRNA in sheep,goats,alpaca and other mammalian skin and hair follicle development.
出处
《中国畜牧兽医》
CAS
北大核心
2016年第9期2373-2378,共6页
China Animal Husbandry & Veterinary Medicine
基金
国家自然科学基金项目(31460585
31206015)
宁夏自治区留学人员创新创业择优资助项目(宁人社函〔2014〕486号)
浙江理工大学科研启动基金项目(16042062-Y)
作者简介
吴月红（1977-）,女,内蒙古赤峰人,博士,副教授,研究方向：干细胞及动物发育生物学,E-mail：wuyh_77@126.com
通信作者：何玉龙,E-mail：heyulong2003@163.com
