摘要
肝门胆管癌是一种少见的起源于胆管上皮细胞的恶性肿瘤。目前肝门胆管癌的主要治疗方式为:手术切除、放疗、化疗、光动力疗法(photodynamic therapy,PDT)。根治性手术切除是目前可能治愈肝门胆管癌并最大限度延长生存期的唯一方法,然而超过一半的患者在确诊时已属肿瘤晚期而丧失手术机会。放疗和化疗能否延长患者生存期仍缺少可靠大数据研究的支持。多数无法行手术治疗的患者为解除胆道梗阻只能行胆道支架置入术,但无法延长生存期。PDT是新兴的一种可以治疗多种恶性肿瘤的方法,已有多项临床研究表明其具有局部消融肿瘤的能力。因此,PDT在治疗不可切除肝门胆管癌有着广阔的应用前景。
Hilar cholangiocarcinoma is a rare biliary malignant tumor derived from the biliary epithelial cell. The primary current treatments for hilar cholangiocarcinoma include surgery and chemotherapy, as well as radiation and photodynamic therapies （PDT）. A complete resection with negative margins is the only treatment with the potential for cure and the only way to maximize survival. Howev- er, over half of the patients in the advanced stage of hilar cholangiocarcinoma lost the chance for surgery. Radiotherapy and chemo- therapy can prolong patient survival; however, these lack reliable data. Most patients who cannot be treated surgically undergo biliary stenting to relieve the biliary obstruction. The PDT is a new method to treat various malignant tumors. Several clinical studies have shown its local tumor ablation capability. Thus, PDT has broad application prospects in the treatment of unresectable hilar cholangiocarcinoma.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2016年第16期735-738,共4页
Chinese Journal of Clinical Oncology
关键词
肝门胆管癌
光动力疗法
光敏剂
支架植入术
生存期
hilar cholangiocarcinoma, photodynamic therapy, photosensitizer, endoprostheses, survival
作者简介
李志原 专业方向为普通外科临床研究。E-mail：1102526725@qq．com
通信作者：崔培元cpy666@126．com
