摘要
目的探讨奥曲肽和七叶皂苷钠联合治疗轻度急性胰腺炎的应用效果。方法将2014年6月至2015年6月该院收治的84例轻度急性胰腺炎患者分为观察组(42例)和对照组(42例)。对照组在常规治疗基础上加用奥曲肽治疗,观察组在对照组治疗基础上加用七叶皂苷钠治疗,疗程均为1周,比较临床疗效、临床症状改善情况、外周血指标及不良反应发生情况。结果观察组治疗总有效率(92.9%)高于对照组(76.2%,P<0.05)。治疗后,观察组恶心呕吐消失时间、腹胀腹痛缓解时间、首次排便时间、住院时间、血淀粉酶、尿淀粉酶,以及血浆C-反应蛋白、肿瘤坏死因子水平均低于对照组(P<0.05)。肠道不适、肝肾功能异常、假性胰腺囊肿、腹痛腹泻等不良反应发生率组间比较差异无统计学意义(P>0.05)。结论奥曲肽和七叶皂苷钠联合治疗轻度急性胰腺炎疗效确切,能有效减少炎性因子分泌,降低血、尿淀粉酶及外周血C-反应蛋白水平,改善临床症状,不良反应少,值得推广应用。
Objective To investigate the clinic effects of combined treatment of octreotide and sodium aescinate in patients with mild acute pancreatitis（MAP） .Methods A total of 84 MAP patients ,treated in this hospital from Jun .2014 to Jun .2015 ,were di-vided into observation group（42 cases） and control group（42 cases） .Patients in control group were treated with octreotide on the basis of routine treatment .Patients in observation group were treated with sodium aescinate on the basis of treatment of control group .Course of treatment was one week .Therapeutic effects ,improvement of clinical symptom ,levels of laboratory parameters and adverse reaction were compared .Results The total efficiency of observation group was 92 .9% ,significantly higher than the 76 .2% of control group（P〈 0 .05） .The nausea and vomiting disappeared time ,bloating and abdominal pain relief time ,the first defecation time ,hospitalization time ,serum amylase ,urine amylase ,C-reaction protein ,tumor necrosis factor-ɑ of the observation group were significantly less than control group after the treatment （P 〈 0 .05） .Incidence of gastrointestinal discomfort ,liver and kidney dysfunction ,pancreatic pseudocyst ,abdominal pain and diarrhea were without significant differences between the two groups （P〉 0 .05） .Conclusion Combined treatment of octreotide and sodium aescinate in MAP patients could be with exact effects ,effec-tively reduce the secretion of inflammatory cytokines ,the levels of blood and urine amylase and C-reaction protein ,improve clinical symptoms ,with fewer side effects ,which might be worthy of promotion .
出处
《检验医学与临床》
CAS
2016年第16期2278-2280,共3页
Laboratory Medicine and Clinic
作者简介
张谨，女，主治医师，主要从事消化内科疾病诊治研究。
