摘要
采用相反转法,以二氯甲烷为溶剂,以Span 80、Tween 80为复合乳化剂,以明胶为稳定剂,成功制备了聚乳酸载青藤碱微胶囊,并利用扫描电子显微镜、傅里叶变换红外光谱仪、粒度分析仪等对微胶囊进行了表征;对微胶囊的载药量、包封率、缓释性能及靶向吸收功效进行了测定.结果表明:制备的微胶囊表面光滑,粒径随着乳化剂比例的增大而减小,载药量及包封率在乳化剂比例为5%的条件下达到了最大值,分别为8.9%和89.2%,且具有缓释功效和肠道靶向吸收功能.
The PLA microcapsules loaded with sinomenine were successfully prepared by phase inversion method using methylene chloride as solvent, Span 80 and Tween 80 as emulsifier, gelatin as stabilizer. The properties of the microcapsules were characterized by scanning electron microscope, Fourier transform infrared spectrometer and particle size analyzer. Drug loading, encapsulation efficiency as well as drug release properties and targeted absorption effect were also determined. The results show that the microcapsules have smooth surface and the particle size is reduced with the increase of the emulsifier ratio. Drug loading and encapsulation efficiency reach the maximum when the emulsifier ratio is at 5%, and the maximum are 8.9%and 89.2%, respectively. Also, the microcapsules have obviously sustained efficacy and targeting intestinal absorption features.
出处
《天津工业大学学报》
CAS
北大核心
2016年第3期6-9,15,共5页
Journal of Tiangong University
基金
国家自然科学基金资助项目(51573135
51203113)
天津市高等学校科技发展基金计划项目(20140305)
国家级大学生创新创业训练计划项目(201410058012)
关键词
相反转法
微胶囊
青藤碱
聚乳酸
缓释
phase inversion method
microcapsules
sinomenine
polylacetic acid
sustained release
作者简介
通信作者：张华（1961-）,女,博士,教授,主要研究方向为生物医学材料.E-mail：hua1210@126.com
