摘要
目的采用Meta分析的方法评价肿瘤坏死因子α(TNF-α)基因启动子-308 G/A位点多态性与中国人群强直性脊柱炎(AS)的相关性。方法计算机检索Pub Med、EMbase、CNKI、CBM、Wan Fang Data及VIP数据库,搜集国内外关于TNF-α基因启动子-308 G/A多态性与中国人群AS相关性的病例-对照研究,检索时限均为建库至2015年12月。由2位研究者独立进行文献筛选、资料提取及纳入研究的偏倚风险评价后,采用Stata 12.0软件行Meta分析。结果最终纳入11个病例-对照研究,包括1 154例AS病例,1 458例对照。Meta分析结果显示:对于中国人群,TNG-α基因-308 G/A位点多态性与AS发病风险相关性无统计学意义[A vs.G:OR=0.96,95%CI(0.63,1.47),P=0.86;AA vs.AG:OR=0.97,95%CI(0.51,1.84),P=0.93;AA vs.GG:OR=0.92,95%CI(0.32,2.61),P=0.87;AA+AG vs.GG:OR=1.04,95%CI(0.60,1.80),P=0.89;AA vs.AG+GG:OR=1.03,95%CI(0.58,1.82),P=0.92]。结论尚不能认为TNF-α基因启动子-308 G/A多态性与中国人群AS发病有关。受纳入研究数量及质量的限制,该结论仍需开展相关研究进行验证。
Objective To evaluate the relationship between tumor necrosis factor-a （TNF-a gene promoter -308 G/A polymorphism and ankylosing spondylitis （AS） in Chinese population by meta-analysis. Methods The case- control studies about the correlation between TNF-a gene polymorphism and AS in Chinese population were retrieved from PubMed, EMbase, CNKI, CBM, WanFang Data and VIP database by two researchers. The retrieval time was from their establishment to December, 2015. After the paper screening, data extraction, and assessment of bias risk, the meta- analysis was conducted by Stata 12.0 software. Results A total of 11 case-control studies involving 1 154 AS patients and 1 458 controls were included. The results of meta-analysis showed that, for Chinese population, there was no significant association between TNF-a -308 G/A polymorphism and AS susceptibility （A vs. G： OR=0.96, 95%CI 0.63 to 1.47, P=0.86; AA vs. AG： OR=0.97, 95%CI 0.51 to 1.84, P=0.93; AA vs. GG： OR=0.92, 95%CI 0.32 to 2.61, P=0.87; AA＋AG vs. GG; OR=1.04, 95%CI 0.60 to 1.80, P=0.89; AA vs. AG＋GG： OR=1.03, 95%CI 0.58 to 1.82, P=0.92）. Conclusion To date, it has not found the relationship between TNF-ct gene promoter -308 G/A polymorphism and AS in Chinese population. For the quantity and quality limitation of the included studies, the conclusion has to be verified by more large-scale high- quality studies.
出处
《中国循证医学杂志》
CSCD
2016年第8期906-912,共7页
Chinese Journal of Evidence-based Medicine
基金
武汉大学自主科研项目基金(编号:2042015 kf 0156)
作者简介
阮晓岚，女（1986年-），主治医师，博士，以血液疾病自循证诊治为主要研究方向。Emaihruanxiaolan1986@163．com
通讯作者，Emaihwengh92@163．com
