摘要
目的探讨细菌感染对川崎病(KD)患儿冠状动脉损伤的关系,为KD的诊疗提供科学参考依据。方法选择2013年3月-2015年3月医院收治KD住院患儿200例,回顾性分析其血液培养和冠状动脉损伤情况,分析细菌感染与冠状动脉损伤的关系,数据采用SPSS 21.0软件进行统计分析。结果 200例KD患儿送检血液样本中23例培养阳性,阳性率为11.50%;共分离出27株病原菌,以革兰阴性菌为主,共16株占69.57%;23例细菌培养阳性患儿中存在冠状动脉损伤15例,占65.22%,177例细菌培养阴性患儿中存在冠状动脉损伤69例,占38.98%,细菌培养阳性患儿的冠状动脉损伤率显著高于阴性患儿,差异有统计学意义(P<0.05)。结论细菌感染可能与KD发病相关,可增加冠状动脉损伤的发生,临床需加强对年长患儿KD细菌感染的预防。
OBJECTIVE To explore the role of bacterial infection in the coronary artery damage in children with Kawasaki disease（KD）,so as to provide the scientific reference for the diagnosis and treatment of KD.METHODS A total of 200 KD children were chosen randomly in hospital from Mar.2013 to Mar.2015.The situation of blood culture and coronary artery damage was analyzed retrospectively,and the relationship of bacterial infection and coronary artery damage were observed.SPSS 21.0was used for data analysis.RESULTS A total of 23 cases were positive among the 200 blood samples,and the positive rate was 11.50%.A total of 27 strains of pathogenic bacteria were isolated,mainly gram-negative bacteria,16 strains,accounting for 69.57%.There were 15cases（accounted for 65.22%）of coronary artery injury in 23 cases of bacterial culture positive children,and 69cases（accounted for 38.98%）in 177 cases of bacterial culture negative children.The rate of coronary artery injury in the positive was significantly higher than that in the negative（P〈0.05）.CONCLUSIONBacterial infection may be associated with the occurrence of KD,which can increase the incidence of coronary artery damage,and we should take more prevention measures on older children to avoid KD.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第15期3564-3566,共3页
Chinese Journal of Nosocomiology
基金
国家自然科学基金资助项目(30672728)
关键词
川崎病
细菌感染
冠状动脉
Kawasaki disease
Bacterial infection
Coronary artery
