摘要
目的了解上海市公共卫生临床中心近5年艾滋病合并中枢神经系统病变的发病情况及各类疾病特点。方法对2010年1月至2015年1月,该中心收治的艾滋病合并中枢神经系统病变病人资料进行回顾性分析。结果期间共收治艾滋病合并中枢神经系统病变病人339例,隐球菌脑膜炎占36.0%(122例),结核性脑膜炎占10.9%(37例),神经梅毒占10.6%(36例),诊断未明占10.0%(34例),弓形虫脑病占10.0%(34例),脑血管疾病占5.0%(17例),进行性多灶性白质脑病占4.4%(15例),混合感染占3.8%(13例),化脓性脑膜炎占3.5%(12例),HIV相关性脑病占2.7%(9例),病毒性脑膜炎占1.2%(4例),非结核分枝杆菌感染占1.2%(4例),颅内肿瘤占0.6%(2例)。除神经梅毒外,各类中枢神经系统病变病人的CD4+T淋巴细胞中位数水平均低于200个/μL,其中隐球菌脑膜炎最低,为21个/μL。诊断未明病人在院病死率最高,为29.4%;其次为结核性脑膜炎16.2%。结论艾滋病合并中枢神经系统病变以隐球菌脑膜炎多见,各类疾病的临床表现多样,CD4+T淋巴细胞中位数低,病死率高。
Objective To investigate the spectrum of central nervous system disorders in HIV/AIDS patients.Methods A retrospective chart review study was used to analyze the patients with central nervous system disorders in the special hospital authorized for AIDS patients.Results Of the 339 patients who were eligible for enrollment,122cases（35.9%）were cryptococcal meningitis,37cases（10.9%）were tuberculous meningitis,36 cases（10.6%）were neurosyphilis,36cases（10.6%）were not clear,34cases（10.2%）were toxoplasma encephalopathy,17cases（5.8%）were cerebrovascular disease,15cases（4.4%）were PML,13case（4.1%）were co-infection,12cases（3.5%）were fester sex meningitis,9cases（2.6%）were HIV-related encephalopathy,4cases（1.1%）were viral meningitis,4cases（1.1%）were non-tuberculosis mycobacteria infection,2cases were intracranial tumor.The mortalities of no-clear diagnosis and tuberculous meningitis were 29.4% and 16.2%.Conclusion Opportunistic infections,such as cryptococcal meningitis,tuberculous meningitis are highly prevalent in central nervous system infection with AIDS patients with wide variety of clinical manifestations.Those patients usually have a low CD4 counts and high mortality.
出处
《中国艾滋病性病》
CAS
北大核心
2016年第7期510-513,共4页
Chinese Journal of Aids & STD
关键词
艾滋病
中枢神经系统病变
疾病谱
Acquired immunodeficiency syndrome
Central nervous system disorders
Spectrum
作者简介
官丽倩（1988-），女，山东省潍坊市人，在读硕士，从事艾滋病相关研究工作。
通信作者：张仁芳，Email：zhangrenfang@shaphe．org
