摘要
目的:研究慢性荨麻疹与幽门螺杆菌(Helicobacter pylori,HP)感染的相关性,探讨HP检测在慢性荨麻疹患者诊疗中的意义。方法:选取2014年4月至2015年7月门诊治疗的慢性荨麻疹患者420例,并随机选取同期体检中心健康体检者450例为健康对照组,采用胶体金法检测患者及健康体检者血清HP尿素酶抗体,分析慢性荨麻疹组和健康对照组两组HP的阳性情况;同时将162例慢性荨麻疹HP阳性患者分为实验组88例和对照组74例,对照组患者应用常规荨麻疹治疗,实验组患者在对照组治疗基础上增加抗HP三联疗法,分析HP检测阳性的慢性荨麻疹患者采用不同治疗方法的临床疗效。结果:慢性荨麻疹组HP阳性率为38.6%,健康对照组HP阳性率为14.4%,差异有统计学意义(P<0.05);HP检测阳性患者实验组临床疗效有效率显著高于对照组的有效率,差异有统计学意义(P<0.05)。结论:慢性荨麻疹与HP感染之间存在密切的相关性,HP检测对慢性荨麻疹患者的诊疗具有重要的临床意义。
Objective： To study the correlation between chronic urticaria and Helicobacter pylori infection,and to explore the significance of HP detection in the diagnosis and treatment of chronic urticaria. Methods： Totally 420 cases of chronic urticaria,who were treated in outpatient department from April 2014 to July 2015,and 450 cases of healthy physical people were selected randomly as healthy control group in the same period,then the serum HP unease antibody was detected by colloidal gold method,the positive rate of two groups patients with HP was analysed. Meanwhile 162 chronic urticaria patients with positive HP were divided into experimental group with 88 cases and control group with 74 cases. The patients in the control group were treated with conventional treatment,while the experimental group were treated with triple therapy based on the treatment of control group,and the clinical efficacy of different therapeutic methods was analysed in the chronic urticaria patients with positive HP. Results： The positive rate of HP in chronic urticaria group was 38. 6%,and the positive rate of HP in healthy control group was 14. 4%,the difference was statistically significant（ P〈0. 05）. The effective rate of clinical efficacy in the experimental group was significantly higher than the control group（ P〈0. 05）. Conclusion： There is close correlation between chronic urticaria and HP infection,HP detection has important clinical significance for the diagnosis and treatment of chronic urticaria.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2016年第7期1050-1052,共3页
Chinese Journal of Immunology
关键词
慢性荨麻疹
幽门螺杆菌
胶体金法
Chronic urticaria
Helicobacter pylori
Colloidal gold method
作者简介
作者简介：王春苗（1986年-），女，硕士，技师，主要从事检验与免疫方面的研究，E-mail：ehunmia0306@163．com。
通讯作者及指导教师：周茂华（1970年-），女，博士，主任技师，主要从事临床免疫方面的研究，E—mail：zmhuagz@126．com。
