摘要
目的探讨血清降钙素原(PCT)联合超敏C反应蛋白(hsCRP)抗菌药物检测在小儿支气管肺炎感染中的临床研究,为诊断小儿支气管肺炎提供临床依据。方法选取2013年6月-2015年6月在医院诊治小儿支气管肺炎患儿113例作为研究对象,根据患儿感染程度分为一般感染组57例和严重感染组56例,再选取体检健康儿童对照组52例,检测每位儿童血清降钙素原(PCT)及超敏C反应蛋白(hsCRP)浓度,比较两组患儿及健康对照组儿童的检测结果。结果治疗前一般感染组及严重感染组患儿PCT水平、hsCRP、WBC计数值明显高于对照组儿童,差异有统计学意义(P<0.05),经药物治疗后,严重感染组患儿的PCT水平、hsCRP、WBC计数值明显高于一般感染组,差异有统计学意义(P<0.05);严重感染组和一般感染组患儿在PCT、hsCRP、WBC检测结果上均与治疗前有差异,且差异统计学意义(P<0.05)。结论小儿肺炎血清PCT水平、hsCRP水平与小儿支气管肺炎严重程度呈正相关,且PCT联合hsCRP检测能显著提高对小儿支气管肺炎的疗效和预后判断,治疗小儿支气管肺炎有指导作用,值得临床上推广。
OBJECTIVE To explore the detection of serum procalcitonin（PCT）combined with high-sensitivity C-reactive protein（hs-CRP）for children with bronchial pneumonia so as to provide guidance for clinical diagnosis of bronchial pneumonia in children.METHODS A total of 113 children with bronchial pneumonia who were treated in the hospital from Jun 2013 to Jun 2015 were recruited as the study objects and divided into the general infection group with 57 cases and the severe infection group with 56 cases according to the severity of the infections,meanwhile,52 healthy children who received physical examination were enrolled in the study.The levels of serum PCT and hs-CRP were detected for all of the enrolled children and were compared between the two groups of children and the children in the control group.RESULTS The level of PCT,hs-CRP,and WBC counts were significantly higher in the children of the general infection group and the severe infection group than in the children of the control group before the treatment（P〈0.05）.After the drug therapy,the level of PCT,hs-CRP,and WBC counts were significantly higher in the children of the severe infection group than in the children of the general infection group（P〈0.05）.There was significant difference in the level of PCT,hs-CRP,or WBC between the severe infection group and the general infection group before and after the treatment（P〈0.05）.CONCLUSIONIn the diagnosis of the children with pneumonia,the levels of serum PCT and hs-CRP are positively correlated with the severity of the bronchial pneumonia,and the detection of PCT combined with hs-CRP can remarkably improve the therapeutic effect of the bronchial pneumonia,facilitate the estimation of prognosis,and provide guidance for treatment of the children with bronchial pneumonia,it is worthy to be promoted in the hospital.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第14期3322-3324,共3页
Chinese Journal of Nosocomiology
基金
湖北省自然科学基金资助项目(2011CDB512)
关键词
超敏C反应蛋白
降钙素原
感染
小儿支气管肺炎
High-sensitivity C-reactive protein
Procalcitonin
Infection
Bronchial pneumonia in child
作者简介
通信作者：黄桂英，E—mail：573824363@qq．com
