摘要
目的探讨右美托咪定对ICU患者血糖以及激素水平的影响。方法选择ICU患者60例为研究对象,按照入院单双号分为研究组和对照组各30例。对照组给予常规治疗,研究组在常规治疗基础上给予右美托咪定治疗。比较两组患者血糖及激素水平。结果研究组在治疗后具有较好的镇静效果(P<0.01);治疗后各个时间段,研究组镇静评分均显著高于对照组(P<0.01)。研究组4 h、8 h、12 h血糖显著升高,在治疗24 h时会下降至正常水平(P<0.01);对照组治疗前后血糖变化不明显(P>0.05)。两组在4 h、8 h、12 h、24 h时血糖存在显著差异(P<0.01),在24 h时研究组显著低于对照组(P<0.01)。研究组治疗24 h时ACTH、C-P、INS水平与治疗前比较有显著差异(P<0.01)。两组治疗后ACTH、C-P、COR及INS比较差异有统计学意义(P<0.01)。结论右美托咪定用于非糖尿病ICU患者的治疗具有较好的镇静作用,患者在用药期间血糖有所升高,因此在用药过程中,应注意监测患者血糖变化。
Objective To discuss the effect of dexmedetomidine on blood glucose and hormone levels of patients in ICU. Methods A total of 60 cases in ICU were selected and divided into study group（30 cases） and control group （30 cases） according to hospital admission order. Study group was treated with dexmedetomidine based on conventional therapy, and control group was treated with conventional therapy. The effect of dexmedetomidine on blood glucose and hormone levels of two groups were compared. Results After treatment, sedative effect of study group was better than control group （P〈0.01）; Each time period after treatment, ramsay score of study group was higher than control group （P〈0.01）. Blood sugar levels of study group at 4 h, 8 h, 12 h were higher, and at 24 h returned to normal（P〈0.01）; There was no significant difference of blood sugar levels in control group before and after treatment （P〉0.05）. There was significant difference of blood sugar levels between the two groups at 4 h, 8 h, 12 h（P〈0.01）; And at 24 h, blood sugar level of study group was lower than control group（P〈0.01）. There was significant difference of ACTH,C-P, INS in study group after 24 h of treatment compared with that before treatment （P〈0.01）; ACTH, C-P, COR and INS of two groups showed significant difference after treatment （P〈0.01）. Conclusion Dexmedetomidine for patients in ICU shows good sedative effect, but blood sugar increases during the medication, so in the course of medication, we should pay attention to monitor the change of blood glucose.
出处
《中国现代医生》
2016年第18期20-22,26,共4页
China Modern Doctor
