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维持性血透患者高磷血症的现状与治疗进展 被引量：21

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摘要 慢性肾脏病（chronic kidney disease,CKD）是严重的世界公共健康问题,占全球人口8%~16%[1]。据报道,我国CKD发病率约为10.8%,终末期肾病发病率为0.04%[2]。慢性肾脏病-矿物质和骨代谢异常（CKD-MBD）是慢性肾脏病患者重要并发症之一,是累及多个系统的症候群,与CKD患者死亡率密切相关。
作者 徐梦露 徐旭东
机构地区 徐州医科大学 复旦大学附属闵行医院/上海市闵行区中心医院
出处 《中国中西医结合肾病杂志》 2016年第6期557-559,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 上海市卫生局中医药科研基金资助项目(No.2012L073A) 上海市闵行区科委基金资助项目(No.2011MHZ65)
关键词 高磷血症 肾脏病患者 终末期肾病 维持性血透 骨代谢 公共健康问题 血液透析 HEMODIALYSIS 血管钙化 甲状旁腺激素
分类号 R459.5 [医药卫生—治疗学]
作者简介 通讯作者
  • 相关文献

参考文献30

  • 1Jha V, Garcia - Garcia G, Iseki K, et al. Chronic kidney disease : global dimension and perspectives, l_ancet,2013,382( 1 ) :260 - 272.
  • 2Chen N, Wang W, Huang Y, et al. Community - based study on CKD subjects and the associated risk factors. Nephrol Dial Trans- plant,2009,24 (12) :2117 - 2123.
  • 3Yu X, Fang Y, Liu H, et al. The balance of beneficial and delete- rious effects of hypoxia - inducible factor activation by prolyl hydroxylase inhibitor in rat remnant kidney depends on the timing of administration. Nephrol Dial Transplant,2012,27 ( 8 ) : 3110 - 3119.
  • 4Reshkin SJ, Forgo J, Biber J, et al. Functional asymmetry of phos- phate transport and its regulation in opossum kidney cells:phos- phate "adaptation". Pflugers Arch, 1991,419 ( 1 ) :256 - 262.
  • 5Palmer SC, Hayen A, Macaskill P, et al. Serum levels of phos- phorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney dis- ease: a systematic review and meta - analysis. JAMA, 2011,305 (11) :1119 - 1127.
  • 6National Kidney F. K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis, 2003,42 ( Suppl 1 ) : S1 - $201.
  • 7Block GA, Klassen PS, Lazarus JM, et al. Mineral metabolism, mortality,and morbidity in maintenance hemodialysis. J Am Soc Nephrol,2004,15(8) :2208 -2218.
  • 8Shinaberger CS, Greenland S, Kopple JD, et al. Is controlling phosphorus by decreasing dietary protein intake beneficial or harmful in persons with chronic kidney disease? Am J Clin Nu- tr,2008,88(6) : 1511 - 1518.
  • 9Sullivan C, Sayre SS, Leon JB, et al. Effect of food additives on hyperphosphatemia among patients with end - stage renal dis- ease : a randomized controlled trial. JAMA, 2009,301 ( 6 ) : 629 - 635.
  • 10Shinaberger CS, Kilpatrick RD, Regidor DL, et al. Longitudinal associations between dietary protein intake and survival in he- modialysis patients. Am J Kidney Dis ,2006,48 ( 1 ) :37 - 49.

二级参考文献32

  • 1Kestenbaum B,Sampson J N,Rudser K D,et al.Serum phosphate levels and mortality risk among people with chronic kidney disease[J].J Am Soc Nephrol,2005,16:520 528.
  • 2Hutchison A J.Improving phosphate-binder therapy as a way forward[J].Nephrol Dial Transplant,2004,19 Suppl 1:i19-i24.
  • 3Mitsopoulos E,Griveas I,Zanos S,et al.Increase in serum magnesium level in haemodialysis patients receiving sevelamcr hydrochloride[J].Int Urol Nephrol,2005,37:321-328.
  • 4Cheng S C,Young D O,Huang Y,et al.A randomized,double-blind,placebo-controlled trial of niacinamide for reduction of phosphorus in hemodialysis patients[J].Clin J Am Soc Nephrol,2008,3:l131-1138.
  • 5Shimoda K,Akiba T,Matsushima T,et al.[Niceritrol decreases serum phosphate levels in chronic hemodialysis patients] [J].Nihon Jinzo Gakkai Shi,1998,40:1-7.
  • 6Jadad A R,Moore R A,Carroll D,et al.Assessing the quality of reports of randomized clinical trials:is blinding necessary?[J].Control Clin Trials,1996,17:l-12.
  • 7Takahashi Y,Tanaka A,Nakamura T,et al.Nicotinamide suppresses hyperphosphatemia in hemodialysis patients[J].Kidney Int,2004,65:1099-1104.
  • 8Young D O,Cheng S C,Delmez J A,et al.The effect of oral niacinamide on plasma phosphorus levels in peritoneal dialysis patients[J].Perit Dial Int,2009,29:562-567.
  • 9Shahbazian H,Zafar M A,Ghorbani A,et al.Oral nicotinamide reduces serum phosphorus,increases HDL,and induces thrombocytopenia in hemodialysis patients:a double blind randomized clinical trial[J].Nefrologia,2011,31:58-65.
  • 10Ahmadi F,Shamekhi F,Lessan-Pezeshki M,et al.Comparison of efficacy of the phosphate binders nicotinic acid and sevelamer hydrochloride in hemodialysis patients[J].Saudi J Kidney Dis Transpl,2012,23:934-938.

共引文献53

同被引文献130

引证文献21

二级引证文献192

中国中西医结合肾病杂志
2016年 第6期

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