摘要
目的探讨克罗恩病(CD)患者术前营养、糖皮质激素应用与术后感染的相关性,为CD术后感染性并发症的预防提供参考。方法收集2010年1月-2015年6月在医院诊断为CD行肠切除吻合手术的103例患者资料,将患者根据术前营养、糖皮质激素使用分组,58例为营养不良组、45例为营养正常组,术前糖皮质激素使用分组29例为糖皮质激素组、74例为无糖皮质激素组,分析术后感染。结果共26例发生感染,感染率为25.24%,感染部位分别为切口感染12例、感染性腹胀腹泻8例、腹腔脓肿2例、感染性吻合口瘘2例、肺部感染及脓毒症各1例,构成比分别为:46.15%、30.77%、7.69%、7.69%、3.85%、3.85%;营养正常组有6例发生感染,感染率为13.33%,营养不良组有20例发生感染,感染率为34.48%,比较差异有统计学意义(P<0.05);无糖皮质激素组有14例发生感染,感染率为18.92%,糖皮质激素组有12例发生感染,感染率为41.38%,比较差异有统计学意义(P<0.05)。结论术前营养、糖皮质激素应用与CD术后感染关系密切,术前营养不良、使用糖皮质激素治疗的患者术后发生感染的风险明显增高。
OBJECTIVE To investigate the correlation of preoperative nutritional,glucocorticoids application and postoperative infection in patients with Crohn＇s disease（CD）,so as to provide reference for CD postoperative infectious prevention.METHODS A total of 103 cases of patients from Jan.2010 to Jun.2015 in the hospital diagnosed as CD line during bowel resection anastomosis operation were collected,and divided into 58 cases of malnutrition group and 45 cases of normal nutrition group,according to the preoperative nutritional status,and 29 cases of glucocorticoid group and 74 cases of no glucocorticoid group,according to the preoperative glucocorticoid usage.The postoperative infectious complications were analyzed.RESULTS There were 26 cases of infections,with the infection rate of 25.24%.The infection sites were 12 cases of incision infection,8cases of infectious abdominal distension diarrhoea,2cases of abdominal abscess,2cases of infectious anastomotic fistula,and 1case of lung infection and 1case of sepsis,accounting for 46.15%,30.77%,7.69%,7.69%,3.85%,and 3.85%,respectively.There were 6cases of infections in normal nutrition group,with the infection rate of 13.33%,and 20 cases of infections in malnutrition group,with the infection rate of 34.48%,and the difference was significant（P〈0.05）.There were 14 cases of infection in no glucocorticoid group,with the infection rate of 18.92%,and 12 cases of infection in glucocorticoid group,with the infection rate of 41.38%,and the difference was significant（P〈0.05）.CONCLUSION Preoperative nutrition and glucocorticoids application with CD was closely related to postoperative infection,preoperative malnutrition and with use of glucocorticoid treatment significantly increased the risk of postoperative infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第13期3002-3004,共3页
Chinese Journal of Nosocomiology
基金
河南省卫生厅基金资助项目(2012209998C)
关键词
术前营养
糖皮质激素
克罗恩病
术后
感染
Preoperative nutrition
Glucocorticoids
Crohn＇s disease
Postoperative
Infectious
